James White, M.D.

Regents Professor
612-626-2846
white003@umn.edu

Educational Background

• St. Thomas College, Minnesota (1951), B.S.
• University of Minnesota, Minnesota (1955), M.D.
• Detroit Receiving Hospital, Michigan (1956), Rotating Internship
• U.S. Army, Fort Mead, Maryland (1958), Pediatrics and ENT
• University of Minnesota, Minnesota (1959), Pediatric Internship
• University of Minnesota, Minnesota (1960), Pediatric Residency
• University of Minnesota, Minnesota (1961), Pediatric Chief Resident
• University of Minnesota, Minnesota (1963), Medical Fellow Specialist

Professional Background

• Assistant Professor, University of Minnesota, Minneapolis, MN, 1963 – 1966
• Associate Professor, University of Minnesota, Minneapolis, MN, 1966 – 1970
• Professor, University of Minnesota, Pediatrics, Minneapolis, MN, 1970 – Present
• Professor, University of Minnesota, Pediatrics, Laboratory Medicine and Pathology, Minneapolis, MN, 1984 – Present
• Regents’ Professor, University of Minnesota, Pediatrics, Laboratory Medicine and Pathology, Minneapolis, MN, 1984 – Present
• Associate Dean for Research, University of Minnesota, Medical School, Minneapolis, MN, 1985 – 1998

Professional Memberships

• Northwest Pediatric Society
• Society for Pediatric Research
• Midwest Society for Pediatric Research
• American Society of Hematology
• Torch Club, International
• American Society for Cell Biology
• American Society for Experimental Pathology
• Central Society for Clinical Investigation
• International Society on Thrombosis and Haemostasis
• American Pediatric Society
• Association of American Physicians
• American Heart Association
• Blood Diseases and Resources Advisory Committee
• Blood Products Advisory Committee
• National Institutes of Health, Parent Committee

Professional Honors

• Dunphy Award, St. Thomas College, 1951
• Maud E. Warwick Scholarship, 1951 – 1952
• Minnesota Medical Foundation Scholarship, 1951 – 1952
• Ski-U-Mah Award, 1955
• Jane Nugent Cochems Prize, 1964
• Mead Johnson Award, 1973
• Elwood A. Sharp Award, 1974
• H.P. Smith Award, 1978
• Edward Kowalski Memorial Lecture (ICTH)
• Regents’ Professor, University of Minnesota, 1984
• Distinguished Career Award, ISTH, 1987
• Gordon Conference on Hemostasis and Thrombosis, Chairman, 1988
• Town and Country Magazine, Outstanding US Pediatric Hematologists, 1989
• Guide to America’s Top Pediatricians, 2005
• International Health Professional of the Year, 2005
• AcademicKeys Who’s Who is Medical Sciences Education, 2005
• Harold S. Diehl Award, 2005
• Editorial Boards: Blood; Blood Cells; Haemostasis; Journal of Laboratory and Clinical Medicine; Arteriosclerosis, Co-Editor; Thrombosis Research; American Journal of Pathology

Recent Publications

• Diaz-Ricart M, Estebanell E, Lozano M, Aznar-Salatti J, White JG, Ordinas A, Escolar G. Thrombin facilitates primary platelet adhesion onto vascular surfaces in the absence of plasma adhesive proteins: studies under flow conditions. Haematologica. 2000 Mar;85(3):280-8.
• Escolar G, White JG. Changes in glycoprotein expression after platelet activation: differences between in vitro and in vivo studies. Thromb Haemost. 2000 Mar;83(3):371-86. Review.
• Lozano M, Escolar G, Mazzara R, Connor J, White JG, DeLecea C, Ordinas A. Effects of the addition of second-messanger effectors to platelet concentrates separated from whole-blood donations and stored at 4 degrees C or -80 degrees C. Transfusion. 2000 May;40(5):527-34.
• McBane RD, Elliot MA, White JG, Charlesworth JE, Costopoulos MG, Owen WG, Nichols WL. Fechtner syndrome: physiologic analysis of macrothrombocytopenia. Blood Coagul Fibrinolysis. 2000 Apr;11(3):243-7.
• Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet. 2000 Mar;24(3):266-70.
• White JG. EDTA-induced changes in platelet structure and function: clot retraction. Platelets. 2000 Feb;11(1):49-55.
• White JG. Platelet secretion during clot retraction. Platelets. 2000 Sep;11(6):331-43.
• White JG, Escolar G. EDTA-induced changes in platelet structure and function: adhesion and spreading. Platelets. 2000 Feb;11(1):56-61.
• Anikster Y, Huizing M, White JG, Shevchenko YO, Fitzpatrick DL, Touchman JW, Compton JG, Bale SJ, Swank RT, Gahl WA, Toro JR. Mutation of a new gene causes a unique form of Hermansky-Pudlak syndrome in a genetic isolate of central Peurto Rico. Nature Genetics. 2001 Aug;28:376-80.
• Erlandsen SL, Bitterman AG, White JG, Marko M. High-resolution cryo-FESEM of individual cell adhesion molecules (CAM) in the glycocalx of human platelets: Detection of P-selectin (CD62P), GPIb/IX complex (CD42a/CD42?,b?), and integrin GPIIbIIIa (CD41/CD61) by immunogold labeling and stereo imaging. J. Histochem.          Cytochem. 2001;49:809-19.
• Falik-Zaccai TC, Anikster Y, Rivera CE, Horne MK 3rd, Schliamser L, Phornphutkul C, Attias D, Hyman T, White JG, Gahl WA. A new genetic isolate of gray platelet syndrome (GPS): clinical, cellular, and hematologic characteristics. Mol Genet Metab. 2001 Nov;74(3):303-13.
• Heath KE, Campos-Barros A, Toren A, Rozenfeld-Granot G, Carlsson LE, Savige J, Denison JC, Gregory MC, White JG, Barker DF, Greinacher A, Epstein CJ, Glucksman MJ, Martignetti JA. Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fecthner, Sebastian, Epstein, and Alport-like syndromes. Am J Hum Genet. 2001 Nov;69(5):1033-45.
• Huizing M, Anikster Y, Fitzpatrick DL, Jeong AB, D'Souza M, Rausche M, Toro JR, Kaiser-Kupfer MI, White JG, Gahl WA. Hermansky-Pudlak syndrome type 3 in Ashkenazi Jews and other non-Peurto Rican patients with hypopigmentation and platelet storage pool deficiency. Am J Hum Genet. 2001 Nov;69:1022-32.
• Huizing M, Anikster Y, White JG, Gahl WA. Characterization of the murine gene corresponding to human Hermansky-Pudlak syndrome type 3: exclusion of the Subtle gray (sut) locus. Mol Genet Metab. 2001 Sep-Oct;74(1-2):217-25.
• Krishnamurti L, Neglia JP, Nagarajan R, Berry SA, Lohr J, Hirsch B, White JG. Paris-Trouseau syndrome platelets in a child with Jacobsen's syndrome. Am J Hematol. 2001 Apr;66(4):295-9.
• Matzdorff AC, White JG, Malzahn K, Greinacher A. Perioperative management of a patient with the Fechtner syndrome. Ann Hematol. 2001 Jul;80(7):436-9.
• Rao GH, Escolar G, White JR, Weiss JR, Burris S, Ordinas A, White JG. Differential response of human and bovine platelets to bovine von Willebrand factor and vascular subendothelium. Platelets 12:150-155, 2001.
• Díaz-Ricart M, Arderiu G, Estebanell E, Pérez-Pujol S, Lozano M, White JG, Escolar G, Ordinas A. Inhibition of cytoskeletal assembly by cytochalasin B prevents signaling through tyrosine phosphorylation and secretion triggered by collagen but not by thrombin. Am J Pathol 2002 Jan;160(1):329-37.
• Fuste B, Diaz-Ricart M, Jensen MK, Ordinas A, Escolar G, White JG. TRAP induces more intense tyrosine phosphorylation than thrombin with differential ultrastructural features. Am J Pathol. 2002 Jun;160(6):2245-52.
• White JG. Disorders affecting Megakaryocytes: Inherited conditions. Blood and Bone Marrow Pathology Platelets. (Wickramasinghe SN and McCullough J, Eds. ) Churchhill Livingston. Elsevier Science Limited. Edinburgh. 2003:493-523.
• White JG. Electron Dense Chains and Clusters in Human Platelets. Platelets. 2002 Aug 1;13(5):317-25.
• White JG. Giant platelet disorders. Hematologica. 87:85-89, 2002.
• White JG. Morphology and ultrastructure of platelets. Platelets in Thrombotic and non-thrombotic disorders: Pathophysiology, Pharmacology and Therapeutics. (Gresele P, Page CP, Fruster V, and Vermylen J, Eds.) Cambridge University Press. New York. 2002: 41-69.
• White JG, de Alarcon P. Platelet spherocytosis: a new bleeding disorder. Am J Hemotol. 2002 Jun;70(2):158-66.
• White JG, Mattson JC, Nichols WL, Greinacher A. A variant of the Sebastian platelet syndrome with unique neutrophil inclusions. Platelets. 2002 Mar;13(2):121-7. Anderson PD, Huizing M, Claassen DA, White JG, Gahl WA. Hermansky-Pudlak syndrome type 4 (HPS-4): Clinical and molecular characteristics. Hum Genet. 2003; 113:10-17.
• White JG. Electron dense chains and clusters in platelets from patients with storage pool deficiency disorders. J Thromb Hemosta. 2003; 1:1-6.
• White JG. Giant electron dense chains, clusters and granules in megakaryocytes and platelets with normal dense bodies: an inherited thrombocytopenic disorder. I. Megakaryocytes. Platelets. 2003; 14:53-60.
• White JG. Giant electron dense chains, clusters and granules in megakaryocytes and platelets with normal dense bodies: An inherited thrombocytopenic disorder. II. Platelet morphology. Platelets. 2003; 14: 109-121.
• White JG. Giant electron dense chains, clusters and granules in megakaryocytes and platelets with normal dense bodies: An inherited thrombocytopenic disorder. III. Platelet analytical electron microscopy. Platelets. 2003; 14: 305-312.
• White JG. Giant electron dense chains, clusters and granules in megakaryocytes and platelets with normal dense bodies: An inherited thrombocytopenic disorder. IV. Ultrastructural cytochemistry and analytical electron microscopy. Platelets. 2003; 14:313-324.
• Rodriguez V,  Nichols WL, Charlesworth JE, White JG. Sebastian platelet syndrome, a hereditary macrothrombocytopenia: case report and review. Mayo Clinic Journal of Medicine.  Mayo Clin Proc.  2003; 78:1416-1421.
• Ekaterini T, Tsilou ET, Rubin BI, Reed GF, McCain L, Huizing M, White JG, Kaiser-Kupfer MI, Gahl W. Milder Ocular Findings in Hermansky-Pudlak Syndrome Type-3 Compared with Hermansky-Pudlak Syndrome Type-1. Opthalmology; 111:1599-1603, 2004.
• Huizing M., Hess R., Dorward H., Claassen D.A., Helip-Wooley A., Kleta R., Kaiser-Kupfer M., White J.G., Gahl W.A.  Cellular, Molecular, and Clinical Characterization of Patients with Hermansky-Pudlak Syndrome Type 5.  Traffic 2004; 5: 711-722. 
• White JG, Key NS, King RA, Vercellotti GM. The white platelet syndrome: A new autosomal dominant platelet disorder.1.Structural abnormalities Platelets.  2004;15:173-184.
• White, JG.  Medich Giant Platelet Disorder:  A Unique ?-granule deficiency.  1. Structural abnormalities.  2004;15: 345-353
• Fuste B, Krogh-Jensen M, Ordinas A, Diaz-Ricart M, Escolar G, White JG.  Differential effect of TRAP (14 mer peptide) and thrombin on platelet activation.  Am J Path 2002; 160:2245-2252.
• White, JG.  Electron microscopy methods for studying platelet structure and function.  In: Methods in Molecular Biology, vol 272: Platelets and Megakaryocytes, vol 1: Functional Assays. (Gibbins M and Makaut-Smith, Eds)  Human Press, Inc, Totown, NJ. pp 47-64.
• White, JG.  Platelets are covercytes, not phagocytes: Uptake of bacteria involves channels of the open canalicular system.  Platelets.  2005; 16: 121-131.
• Zarzour W, Kleta R, Frangoul H, Suwannarat P, Jeong A, Kim SY, Wayne AS,Gunay-Aygun M, White JG, Filipovich A, and Gahl W: Two Novel:  CHS1 (LYST) mutations:      Clinical correlations in an infant with Chediak-Higashi syndrome.  Molecular Genetics and Metabolism.  2005; 85:125-132.
• White, JG.  Golgi complexes in hypogranular platelet disorders.  Platelets.  2005; 16:51-60. 
• White JG, Key NS, King RA, Vercellotti GM: A Touch of the White Platelet Syndrome.  Platelets. 2005; 16:346-361
• Lederer DJ., Kawut SM., Sonett JR., Vakiani E., Seward SL., White JG., Wilt JS.,   Marboe CC., Gahl WA., Arcasoy SM.  Successful Bilateral Lung Transplantation for Pulmonary Fibrosis Associated With the Hermansky-Pudlak Syndrome.  Journal of Heart and Lung Transpantation.  2005; 24:1697-1699.
• White JG, Brunning RD. Neutrophils in the gray platelet syndrome.Platelets; 2004; 15:333-340