Michael Steffes, M.D., Ph.D.

Professor
612-624-8164
steff001@umn.edu

Educational Background

• Harvard College, Cambridge, MA (1965), A.B. (Biology)
• University of Minnesota (1970), Ph.D. (Anatomy)
• University of Minnesota (1970), M.D.
• University of Minnesota (1974), Residency (Laboratory Medicine)

Professional Background

• Assistant Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 1974 - 1977
• Director, Division of Clinical Chemistry, University of Minnesota, 1976 - 1984
• Associate Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 1977 - 1981
• Director, Clinical Laboratories, University of Minnesota, 1984 - 1992
• Director, Laboratory Clinical Service, University of Minnesota, 1992 - 1995
• Director, Special Chemistry Service, University of Minnesota, 1995 - present
• Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 1981 - present

Professional Honors

• Diabetes Training Fellowship, NIH, 1966 - 1967
• Life Insurance Medical Research Fund Fellow, 1967 - 1970
• Fogarty Senior International Fellowship, 1979 - 1980
• Max Miller Sugar Club Lectureship, 1989
• Kellion Lectureship (Melbourne, Brisbane and Perth, Australia), Australian Diabetes Society Annual Meeting, 1990
• David Rumbough Award, Juvenile Diabetes Foundation, International, 1996

Publications

• Bilous RW, Mauer SM, Sutherland DER, Najarian JS, Goetz FC, Steffes MW. The effects of pancreas transplantation on the glomerular structure of renal allografts in patients with insulin-dependent diabetes. The New England Journal of Medicine 321:80-85, 1989.
• Ellis EN, Mauer SM, Sutherland DER, Steffes MW. Glomerular capillary morphology in normal man. Laboratory Investigation 60:231-236, 1989.
• Mauer SM, Goetz FC, McHugh LE, Sutherland DER, Najarian JS, Barbosa J, Steffes MW. Long-term study of normal kidneys transplanted into patients with type I diabetes. Diabetes 38:516-523, 1989.
• Chavers BM, Bilous RW, Ellis EN, Steffes MW, Mauer SM. Glomerular lesions and urinary albumin excretion in type 1 diabetes without overt proteinuria. The New England Journal of Medicine 320: 966-970, 1989.
• Mauer SM, Steffes MW, Azar S, Brown DM. Effects of sorbinil on glomerular structure and function in long-term diabetic rats. Diabetes 38:839-846, 1989.
• Bilous RW, Mauer SM, Sutherland DER, Steffes MW. Mean glomerular volume and the rate of development of diabetic nephropathy. Diabetes 38:1142-1147, 1989.
• Harris RD, Steffes MW, Bilous RW, Sutherland DER, Mauer SM. Global glomerular sclerosis and glomerular arteriolar hyalinosis in insulin dependent diabetes. Kidney International 40:107-114, 1991.
• Lane PH, Steffes MW, Mauer SM. Glomerular structure in IDDM women with low glomerular filtration rate and normal urinary albumin excretion. Diabetes 41:581-586, 1992.
• Steffes MW, Bilous RW, Sutherland DER, Mauer SM. Cell and matrix components of the glomerular mesangium in type I diabetes mellitus. Diabetes 41:679-684, 1992.
• Mauer SM, Sutherland DER, Steffes MW. Relationship of systemic blood pressure to nephropathology in insulin dependent diabetes mellitus (IDDM). Kidney International 41:736-740, 1992.
• Lane PH, Steffes MW, Mauer SM. Estimation of glomerular volume: A comparison of four methods. Kidney International 41:1085-1089, 1992.
• Hattori M, Kim Y, Steffes MW, Mauer SM. Structural-functional relationships in type I mesangiocapillary glomerulonephritis. Kidney International 43:381-386, 1993.
• Lane PH, Steffes MW, Fioretto P, Mauer SM. Renal interstitial expansion in insulin-dependent diabetes mellitus. Kidney International 43:661-667, 1993.
• Fioretto P, Mauer SM, Bilous RW, Goetz FC, Sutherland DER, Steffes MW. Effects of pancreas transplantation on glomerular structure in insulin-dependent diabetic patients with their own kidneys. The Lancet 342:1193-96, 1993.
• Zhu D, Kim Y, Steffes MW, Groppoli TJ, Butkowski RJ, Mauer SM. Application of electron microscopic immunocytochemistry to the human kidney: Distribution of type IV and type VI collagen in the normal human kidney. Journal of Histochemistry and Cytochemistry 42:577-84, 1994.
• Barbosa J, Steffes M, Sutherland D, Connett J, Rao V, Mauer SM. The effect of glycemic control on early diabetic renal lesions. Journal of the American Medical Association 272:600-606, 1994.
• Fioretto P, Steffes MW, Mauer SM. Glomerular structure in non-proteinuric insulin-dependent diabetic patients with various levels of albuminuria. Diabetes 43:1358-1364, 1994.
• Chavers BM, Mauer SM, Ramsey RC, Steffes MW. Relationship between retinal and glomerular lesions in patients with type I diabetes mellitus. Diabetes 43:441-46, 1994.
• Basgen JM, Steffes MW, Stillman AE, Mauer SM. Estimating glomerular number in situ using magnetic resonance imaging and biopsy. Kidney International 45:1668-1672, 1994.
• Vlassara H, Striker LJ, Teichberg S, Fuh H, Li YM, Steffes MW. Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats Proceedings of the National Academy of Science 91:11704-708, 1994.
• Fioretto P, Steffes MW, Mihatsch MJ, Strøm EH, Sutherland DER, Mauer SM. Cyclosporine associated lesions in native kidneys of diabetic pancreas transplant recipients Kidney International 48:489-495, 1995.
• Fioretto P, Steffes MW, Sutherland DER, Mauer SM. Sequential renal biopsies in insulin-dependent diabetic patients: Structural factors associated with clinical progression Kidney International 48:1929-1935, 1995.
• Li YM, Steffes MW, Donnelly, T, Liu C, Fuh H, Basgen, J, Bucala, R, Vlassara H. Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine Proceedings of the National Academy of Science 93:3902-907, 1996.
• DCCT Research Group. The effect of intensive diabetes treatment on residual beta-cell function in the Diabetes Control and Complications Trial. Ann Int Med 128:517-23, 1998.
• Brito P, Drummond K, Kim Y, Steffes MW, Basgen JM, Mauer SM. The relationships between tubular basement membrane, glomerular basement membrane and mesangial expansion in insulin-dependent diabetes mellitus (IDDM). Kidney International 53:754-61, 1998.
• Fioretto P, Steffes MW, Sutherland DER, Geotz FC, Mauer SM. Reversal of diabetic nephropathy by pancreas transplantation. N. Eng. J. Med. 339:69-75, 1998.
• Purnell JQ, Hokanson JE, Marcovina SM, Cleary PA,Steffes MW, Brunzell JD. Effect of excessive weight gain with intensive therapy of type 1 diabetes on lipid levels and blood pressure. Journal of the American Medical Association 280:140-46, 1998.
• Fioretto P, Steffes MW, Barbosa J, Rich SS, Mauer M. Is diabetic nephropathy inherited? Studies of glomerular structure in type 1 diabetic sibling pairs. Diabetes 48:865-69, 1999.
• DCCT/EDIC Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N. Eng. J. Med. 342:381-389, 2000.
• Thomas W, Shen Y, Molitch ME, Steffes MW. Rise in albuminuria and blood pressure in patients who progressed to diabetic nephropathy in the Diabetes Control and Complications Trial. J. Amer. Soc. Nephrol. 12:333-40, 2001.
• Degenhardt TP, Alderson NL, Arrington DD, Beattie RJ, Basgen JM, Steffes MW, Thorpe SR, Baynes JW. Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat. Kidney International. 61(3):939-50, 2002.
• Steffes MW, Schmidt D, McCrery R, Basgen JM. The International Diabetic Nephropathy Study Group. Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Intl. 59(6):2104-13, 2001.
• Sibley SD, Hokanson JE, Steffes MW, Purnell JQ, Marcovina SM, Cleary PA, Brunzell JD. Increased small dense LDL and intermediate-density lipoprotein with albuminuria in type 1 diabetes. Diabetes Care. 22(7):1165-70, 1999.
• DCCT Research Group. Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT). J Pediatr 139:804-12-20, 2001.
• Jacobs DR, Jr., Murtaugh MA, Steffes M, Yu X, Roseman J, Goetz FC. Gender and race-specific determinations of albumin excretion rate using albumin to creatinine ratio in single untimed urine specimens: the CARDIA study. Am J Epidemiol 155:1114-19, 2002.
• DCCT/EDIC Research Group. Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA 287:2563-69, 2002.
• Feng Z, He C, Cai W, Hattori M, Steffes M, Vlassara H, Prevention of Diabetic Nephropathy by a Diet Low in Glycoxidation Products in Mice. Diab Metab Res Rev 18: 224-37, 2002.
• Moriya T, Moriya R, Yajima Y, Steffes MW, Mauer M. Urinary albumin as an indicator of diabetic nephropathy lesions in Japanese type 2 diabetic patients. Nephron 91: 292-9, 2002.
• Waters D, Alderman E, Hsia J, Howard B, Cobb F, Rogers W, Ouyang P, Thompson P, Tardif JC, Higginson L, Bittner V, Steffes M, Gordon D, Proschan M, Younes N, Verter J. Effects of Hormone Replacement Therapy and Antioxidant Vitamin Supplements on Coronary Atherosclerosis in Postmenopausal Women: A Randomized Controlled Trial. JAMA 288:2432-2440, 2002.
• Steffes MW, Sibley S, Jackson M, Thomas W. Beta Cell Function and the Development of Diabetes-related Complications in the Diabetes Control and Complications Trial (DCCT) Diabetes Care 26: 292-9, 2003.
• Murtaugh MA, Jacobs DR, Jr., Steffes MW, Yu X Urinary albumin excretion increases with blood pressure in black and white young adults: the CARDIA study Am J Epidemiol 212: 676-86, 2003
• Purnell, JQ, Dev, RK, Steffes, MW, Cleary, PA, Palmer, JP, Hirsch, IB, Hokanson, JE, Brunzell, JD, Relationship of family history of type-2 diabetes and hypoglycemia to weight gain and lipid levels with intensive and conventional therapy in the Diabetes Control and Complications Trial. Diabetes 52: 2623-29, 2003
• Lee, DH, Ha, MH, Kim, JH, Christiani, DC, Gross M, Steffes M, Blomhoff, R, Jacobs DR. Gamma-glutamyltransferase and type 2 diabetes- A 4 years follow-up study. Clinical Chemistry 49: 1358-66, 2003
• DCCT/EDIC Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy. JAMA 290:2159-67, 2003.
• Stehman-Breen CO, Gillen D, Steffes MW, Jacobs D, Lewis CE, Kiefe C, Siscovick D. Racial and gender disparities in early onset renal disease among young adults - the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Journal American Society of Nephrology 14: 2352-7, 2003
• Lee DH, Ha MH, Kim JH, Christiani DC, Gross MD, Steffes M, Blomhoff R, Jacobs DR. Gamma-glutamyltransferase and diabetes - a 4 year follow-up study. Diabetologia 46: 359-64, 2003
• Expert Committee of the American Diabetes Association (Multiple authors including Michael Steffes), Follow-up report on the diagnosis of diabetes mellitus Diabetes Care 26: 3160-7, 2003
• Levey AS , Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Int Med 139: 137-47, 2003
• Bittner V, Tripputi M, Hsia J, Gupta H, Steffes M for the WAVE Investigators. Remnant like lipoproteins, hormone therapy, and angiographic and clinical outcomes: The Women's Angiographic Vitamin & Estrogen Trial (WAVE). American Heart Journal, In press 2004
• Reboussin DM, Goff DC, Lipkin EW, Herrington DM, Summerson J, Steffes M, Crouse III RJ, Jovanovic L, Feinglos MN, Probstfield JL, Banerji MA, Pettitt DJ, Williamson J. The combination oral and nutritional treatment of late onset diabetes mellitus (CONTROL DM) trial results. Diabet. Med., In press 2004
• Palmer JP, Fleming G A, Greenbaum CJ, Herold KC, Jansa LD, Kolb H, Lachin JM, Polonsky KS, Pozzilli P, Skyler JS, Steffes MW. C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 53: 250-64, 2004
• Molitch ME, DeFronzo RA, Franz MJ, Keane WF, Mogensen CE, Parving HH, Steffes MW. Nephropathy in diabetes. Diabetes Care 27 Suppl 1 S79-S83, 2004
• Gross M, Steffes MW, Jacobs D, Yu X, Lewis L, Lewis CE, Hilner J, Loria CM. Plasma F2-Isoprostanes and Coronary Artery Calcification: The CARDIA Study. Clinical Chemistry 51: 125-31, 2005.
• Steffes M, Cleary P, Goldstein D, Little R, Wiedmeyer H, Rohlfing C, England J, Bucksa J, Nowicki M, and the DCCT/EDIC Research Group. Glycated Hemoglobin (HbA1c) Measurements over Nearly Two Decades: sustaining comparable values throughout the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications Study. Clinical Chemistry 51:753-58, 2005.
• Selvin E, Coresh J, Golden SH; Brancati, FL; Folsom AL; Steffes MW. Glycemic Control and Coronary Heart Disease Risk in Persons with and without Diabetes: The Atherosclerosis Risk in Communities Study. Archives of Internal Medicine (in press) 2005