Stefan E. Pambuccian, M.D.

Assistant Professor
pambu001@umn.edu

Dr. Pambuccian is an Assistant Professor of Laboratory Medicine and Pathology and Director of Cytopathology at University of Minnesota Medical Center, Fairview.  Dr. Pambucian teaches and lectures to residents and fellows in surgical, autopsy, and cytopathology.  He has a special interest in ENT pathology and the use of digital imaging technology in the practice of pathology. 

Educational Background

• University Bucharest Medical School, Bucharest, Romania (1983), M.D.
• University of Bucharest Medical School Affiliated Hospitals (1986), Residency (Family Practice)
• Lenox Hill Hospital, New York, NY (1994), Residency (Anatomic and Clinical Pathology)
• Lenox Hill Hospital, New York, NY (1995), Fellowship (Surgical Pathology/Hematopathology)
• Johns Hopkins Hospital, Baltimore, MD (1996), Fellowship (Cytopathology)

Board Certification

Anatomic and Clinical Pathology, Cytopathology

Professional Background

• Family Practitioner, Private Practice, 1986 - 1989
• Pathologist, IMPATH Laboratories, New York, NY, Immunohistochemistry,cell prolif.,&ca prognostic markers, 1994 - 1995
• Fellow, Armed Forces Institute of Pathology, Washington, DC, Cellular/Quantitative Pathology/Telepathology, 1995 - 1996
• Assistant Professor, University of Minnesota Medical School, Laboratory Medicine and Pathology, 1996 - present
• Staff Surgical Pathologist & Cytopathologist, Director of Cytopathology, University of Minnesota Medical Center, Fairview, 1996 - present

Publications

Dr. Pambuccian has written on topics such as disseminated acanthamoeba infection masquerading as bacillary angiomatosis in a patient with AIDS, B lymphoid monoclonal antibodies reactive with lung tumors- diagnostic applications, amyloidoma of bone (a plasma cell plasmacytoid neoplasm), and salivary duct carcinoma- a specific diagnosis possible by fine needle aspiration cytology.

• Ioachim HL, Pambuccian S, Giancotti F, Dorsett B. Reactivity of lung tumors with lung-derived and non-lung-derived monoclonal antibodies. Int J Cancer Suppl. 8:132-3, 1994.
• Ioachim HL, Pambuccian SE, Hekimgil M, Giancotti FR, Dorsett BH. Lymphoid monoclonal antibodies reactive with lung tumors. Diagnostic applications. Am J Surg Pathol. 20(1):64-71, 1996.
• Pambuccian SE, Becker RL Jr, Ali SZ, Savik K, Rosenthal DL. Differential diagnosis of Hurthle cell neoplasms on fine needle aspirates. Can we do any better with morphometry? Acta Cytol. 41(1):197-208, 1997.
• Pambuccian SE, Horyd ID, Cawte T, Huvos AG. Amyloidoma of bone, a plasma cell/plasmacytoid neoplasm. Report of three cases and review of the literature. Am J Surg Pathol. 21(2):179-86.
• Pambuccian SE, Horyd ID, Cawte T, Huvos AG. Amyloidoma of bone, a plasma cell/plasmacytoid neoplasm. Report of three cases and review of the literature. [see comments.]. [Review] [55 refs] American Journal of Surgical Pathology. 21(2):179-86, 1997.
• Gilcrease MZ, Guzman-Paz M, Froberg K, Pambuccian S. Salivary duct carcinoma. Is a specific diagnosis possible by fine needle aspiration cytology? Acta Cytol. 1998 Nov-Dec;42(6):1389-96, 1998.
• Pambuccian SE, Bachowski GJ, Twiggs LB. Signet ring cell lobular carcinoma of the breast presenting in a cervicovaginal smear. A case report. Acta Cytol. 4(5):824-30, 2000.
• Solomon RK, Lundeen SJ, Hamlar DD, Pambuccian SE. Fine-needle aspiration diagnosis of unusual cutaneous neoplasms of the scalp in HIV-infected patients: A report of two cases and review of the literature. Diagn Cytopathol. 24(3):186-92, 2001.
• Casey RC, Burleson KM, Skubitz KM, Pambuccian SE, Oegema TR Jr., Ruff LE, Skubitz AP. Beta 1-integrins regulate the formation and adhesion of ovarian carcinoma multicellular spheroids. American Journal of Pathology. 159(6):2071-80, 2001.
• Pettinato G. Di Vizio D. Manivel JC. Pambuccian SE. Somma P. Insabato L. Solid-pseudopapillary tumor of the pancreas: a neoplasm with distinct and highly characteristic cytological features. [Review] [87 refs] Diagnostic Cytopathology. 27(6):325-34, 2002.
• Pettinato G. Pambuccian SE. Di Prisco B. Manivel JC. Fine needle aspiration cytology of invasive micropapillary (pseudopapillary) carcinoma of the breast. Report of 11 cases with clinicopathologic findings. Acta Cytologica. 46(6):1088-94, 2002.
• Casey RC, Oegema TR, Skubitz KM, Pambuccian SE, Grindle SM, and Skubitz APN. Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cells. Clinical and Experimental Metastasis 20:143-152, 2003.
• Casey RC, Koch KA, Oegema TR, Skubitz KM, Pambuccian SE, Grindle SM, and Skubitz APN. Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayers, Clin. Exp. Met. 20:343-356.
• Gulbahce HE. Baker KS. Kumar P. Kjeldahl K. Pambuccian SE. Atypical cells in bronchoalveolar lavage specimens from bone marrow transplant recipients. A potential pitfall. American Journal of Clinical Pathology. 120(1):101-6, 2003.
• Stelow EB. Stanley MW. Bardales RH. Mallery S. Lai R. Linzie BM. Pambuccian SE. Intraductal papillary-mucinous neoplasm of the pancreas. The findings and limitations of cytologic samples obtained by endoscopic ultrasound-guided fine-needle aspiration. American Journal of Clinical Pathology. 120(3):398-404, 2003.
• Hibbs, K., Skubitz, K.M., Pambuccian, S.E., Casey, R.C., Burleson, K.M, Oegema, T.R., Thiele, J.J., Grindle, S.M., Bliss, R.L., and Skubitz, A.P.N. "Differential gene expression in ovarian carcinoma: Identification of potential biomarkers," Am. J. Pathol. 2004 (in press).
• Burleson, K.M., Casey, R.C., Skubitz, K.M., Pambuccian, S.E., Oegema, T.R., and Skubitz, A.P.N. (2004) Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers. Gynecologic Oncology 93(1):170-81