Home > Faculty and Staff > Tucker W. LeBien, Ph.D.
Tucker W. LeBien, Ph.D.
Professor 612-626-1422 lebie001@umn.edu
Educational Background
- North Dakota State University, North Dakota (1970), B.S. (Zoology)
- North Dakota State University, North Dakota (1973), M.S. (Bacteriology)
- University of Nebraska Medical Center, Nebraska (1977), Ph.D. (Medical Microbiology – Immunology)
Professional Background
- Research Assistant, University of Nebraska Medical Center, Department of Medical Microbiology, Omaha, NE, 1974 – 1977
- Postdoctoral Fellow, University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 1977 – 1979
- Instructor, University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 1979 – 1980
- Assistant Professor, University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 1980 – 1984
- Associate Professor, University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 1984 – 1989
- Visiting Associate Professor of Pathology, Harvard Medical School, Laboratory of Molecular Immunology, Boston, MA, 1986
- Director of Graduate Studies, University of Minnesota, Pathobiology Graduate Program, Minneapolis, MN, 1988 – 1993
- Professor, University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 1989 – Present
- Director, University of Minnesota, NIAID Immunology Predoctoral Training Program, Minneapolis, MN, 1989 – 2002
- Chair, Leukemia Task Force/ Leukemia Research Fund, 1994 – Present
- Associate Director for Basic Research, University of Minnesota Cancer Center, Minneapolis, MN, 1994 – Present
- Director, Flow Cytometry Core, 1996 – Present
- Deputy Director, University of Minnesota Cancer Center, Minneapolis, MN, 1997 – Present
- Director, University of Minnesota, NIH Medical Scientist Training Program, Minneapolis, MN, 2003 – Present
- Director, University of Minnesota, Combined M.D./ Ph.D Program, Minneapolis, MN, 2003 - Present
Professional Memberships
- American Association of Immunologists
- American Association for Cancer Research
- American Society of Hematology
- American Association for the Advancement of Science
- International Society for Experimental Hematology
Professional Honors
- Alumni Achievement Award, North Dakota State University, 2002
- Apogee Enterprises Chair in Cancer Research, 1999 – Present
- Associate Editor, Blood, 1991 – 1997
- Stohlman Memorial Award, Leukemia Society of America, 1989
- McFadden Lectureship, Nebraska Medical Center, 1987
- Short Term Scientific Exchange Award, Leukemia Society of America, 1986
- Award of Excellence, Alison Eberlein Fund, Inc., 1984
- Scholar of the Leukemia Society of America, 19984 – 1989
- Travel Scholarships to: IV Int. Cong. Of Immunology, Paris, 1980; X. Cong. of the Int. Soc. for Experimental Hematology, Munich, 1981; V. Int. Cong. of Immunology, Kyoto, 1983; 3rd National Conference of the Leukemia Society of America, San Diego, 1987.
- National Cancer Institute New Investigator Award, 1980 - 1982
Publications
Tucker LeBien has served on the Editorial Boards for Experimental Hematology, 2002 – 2006; Blood, 1988 – 1990; Leukemia, 1987 – 1996; Leukemia Research, 1985 – 1986; Journal of Immunology, 1984 – 1988.
- LeBien, T.W. and M.C. Bromel. 1975. A peroxidogenic strain of Streptococcus mitior (mitis). Can. J. Microbiol. 21:101-103.
- LeBien, T.W. 1975. RNA tumor viruses (letter to the editor). J. Amer. Med. Assoc. 232:1127.
- LeBien, T.W., R.L. Hurwitz, and J.H. Kersey. 1979. Characterization of a xenoantiserum produced against three molar KCL solubilized antigens obtained from a non-T, non-B (pre-B) acute lymphoblastic leukemia cell line. J. Immunol. 122:82-88.
- Hurwitz, R., J. Hozier, T. LeBien, J. Minowada, K. Gajl-Peczalska, I. Kubonishi, and J.H. Kersey. 1979. Characterization of a leukemic cell line of the pre-B phenotype. Int. J. Cancer 23:174-180.
- LeBien, T.W., J. Hozier, J. Minowada, and J.H. Kersey. 1979. Origin of chronic myelocytic leukemia in a precursor of pre-B lymphocytes. N. Engl. J. Med. 301:144-147.
- Kersey, J.H., T.W. LeBien, R.L. Hurwitz, M. Nesbit, K. Gajl-Peczalska, D. Hammond, D.R. Miller, P.F. Coccia, and S. Leikin. 1979. Childhood leukemia-lymphoma: Heterogeneity of phenotypes and prognoses. Amer. J. Clin. Pathol. 72:746-752.
- Kersey, J.H., R.L. Hurwitz, and T.W. LeBien. 1980. Childhood leukemia-lymphoma. In: Pediatrics Update. Edited by A.J. Moss, Elsevier, New York, pp. 328-343.
- Priest, J., L.L. Robison, R.W. McKenna, L.L. Lindquist, P.I. Warkentin, T.W. LeBien, W.G. Woods, J.H. Kersey, P.F. Coccia, and M.E. Nesbit, Jr. 1980. Philadelphia chromosome positive childhood acute lymphoblastic leukemia. Blood 56:15-22.
- Hozier, J., L. Lindquist, R. Hurwitz, T. LeBien, and J. Kersey. 1980. Evolution of cultured leukemia cell lines monitored by chromosomal and immunologic analysis: Implications for B-cell differentiation. Int. J. Cancer 26:281-284.
- LeBien, T.W., J.L. Parkin, R.D. Brunning, and J.H. Kersey. 1980. Immunologic and ultrastructural heterogeneity of acute lymphoblastic leukemia-associated antigen (CALLA) positive leukemias. J. Natl. Cancer Inst. 65:1231-1236.
- LeBien, T.W. and J.H. Kersey. 1980. A monoclonal antibody (TA-1) reactive with human T lymphocytes and monocytes. J. Immunol. 125:2208-2214.
- Abramson, C., J.H. Kersey, and T.W. LeBien. 1981. A monoclonal antibody (BA-1) primarily reactive with cells of human B lymphocyte lineage. J. Immunol. 126:83-88.
- Kersey, J.H., T.W. LeBien, C.S. Abramson, R. Newman, R. Sutherland, and M. Greaves. 1981. p24: A human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody. J. Exp. Med. 153:726-731.
- LeBien, T.W., R. McKenna, C. Abramson, K. Gajl-Peczalska, M. Nesbit, P. Coccia, C. Bloomfield, and J. Kersey. 1981. The use of monoclonal antibodies, morphology, and cytochemistry to probe the cellular heterogeneity of acute leukemia and lymphoma. Cancer Res. 41 (November, Part 2):4776-4780.
- Bloomfield, C.D., L.L. Lindquist, D. Arthur, R.W. McKenna, T.W. LeBien, B.A. Peterson, and M.E. Nesbit. 1981. Chromosomal abnormalities in acute lymphoblastic leukemia. Cancer Res. 41 (November, Part 2):4838-4843.
- LeBien, T.W. 1981. Letter to the Editor. Blood 58:1240.
- LeBien, T.W. 1981. Monoclonal antibodies and human disease. Human Pathol. 12:679-681.
- LeBien, T.W., C.J. Brashem, C.S. Abramson, E.M. Frenzel, F.J. Bollum, and J.H. Kersey. 1981. Studies of human lymphopoiesis with monoclonal antibodies BA-1 and BA-2. In: Leukemia Markers W. Knapp, ed. Academic Press Inc., pp. 81-84.
- Kersey, J.H., T.W. LeBien, K.J. Gajl-Peczalaska, M. Nesbit, J. Jansen, P. Kung, G. Goldstein, H. Sather, P. Coccia, S. Siegal, A. Bleyer, and D. Hammond. 1981. Acute lymphoblastic leukemia/lymphoma: Cell markers define phenotypic heterogeneity. In: Leukemia Markers W. Knapp, ed., Academic Press Inc., pp. 453-462.
- Jansen, J., H.R.E. Schuit, C. Meijer, T.W. LeBien, W. Hijmans, and J.H. Kersey. 1981. Cell markers in hairy-cell leukemia. In: Leukemia Markers W. Knapp, ed., Academic Press Inc., pp. 179-192.
- LeBien, T.W., D.R. Boué, and J.H. Kersey. 1982. Studies of human leukemia lymphoid progenitor cell differentiation with the phorbol ester TPA. In: Experimental Hematology Today 1982 Edited by S. Baum, C.D. Ledney, and S. Thierfelder, Springer Verlag, New York. pp. 171-178.
- LeBien, T.W., F.J. Bollum, W.G. Yasmineh, and J.H. Kersey. 1982. Phorbol ester-induced differentiation of a non-T, non-B leukemic cell line: model for human lymphoid progenitor cell development. J. Immunol. 128:1283-1287.
- Platt, J.L., T.W. LeBien, and A.F. Michael. 1982. Interstitial mononuclear cell populations in renal graft rejection. Identification by monoclonal antibodies in tissue sections. J. Exp. Med. 155:17-30.
- Jansen, J., T.W. LeBien, and J.H. Kersey. 1982. The phenotype of the neoplastic cells of hairy cell leukemia studied with monoclonal antibodies. Blood 59:609-614.
- LeBien, T.W., J.H. Kersey, S. Nakazawa, K. Minato, and J. Minowada. 1982. Analysis of human leukemia/lymphoma cell lines with monoclonal antibodies BA-1, BA-2, and BA-3. Leuk. Res. 6:299-305.
- Jansen, J., R.C. Ash, E.D. Zanjani, T.W. LeBien, and J.H. Kersey. 1982. Monoclonal antibody BA-1 does not bind to hematopoietic precursor cells. Blood 59:1029-1035.
- Newman, R.A., D.R. Sutherland, T.W. LeBien, J.H. Kersey, and M.F. Greaves. 1982. Biochemical characterization of leukemia associated antigen p24 defined by the monoclonal antibody BA-2. Biochem et Biophys Acta 701:318-327.
- Gajl-Peczalska, K.J., C.D. Bloomfield, G. Frizzera, J.H. Kersey, and T.W. LeBien. 1982. Diversity of phenotypes of non-Hodgkins malignant lymphoma. In: B and T Cell Tumors: Biological and Clinical Aspects E. Vitetta, ed. Academic Press Inc., pp. 63-67.
- LeBien, T.W. and J.H. Kersey. 1982. Analysis of normal and malignant lymphoid progenitor cells with monoclonal antibodies. In: Proc. of the Second NCI/EPA/NIOSH Collaborative Workshop H.F. Kraybill, I.C. Blackwood, and N.B. Freas, eds., pp. 622-631.
- LeBien, T.W., D.R. Boué, J.G. Bradley, and J.H. Kersey. 1982. Antibody affinity may influence antigenic modulation of the common acute lymphoblastic leukemia antigen in vitro. J.Immunol. 129:2287-2292.
- Ash, R.C., J. Jansen, J.H. Kersey, T.W. LeBien, and E.D. Zanjani. 1982. Normal human pluripotential and committed hematopoietic progenitors do not express the p24 antigen detected by monoclonal antibody BA-2: Implications for immunotherapy of lymphocytic leukemia. Blood 60:1310-1316.
- Brashem, C.J., J.H. Kersey, F.J. Bollum, and T.W. LeBien. 1982. Ontogenic studies of human bone marrow lymphoid progenitor cells. Exper. Hematol. 10:886-892.
- Kersey, J., A. Goldman, C. Abramson, M. Nesbit, G. Perry, K. Gajl-Peczalska and T. LeBien. 1982. The clinical utility of monoclonal antibody phenotyping in childhood acute lymphoblastic leukemia. Lancet II:1419-1423.
- LeBien, T.W., R.C. Ash, E.D. Zanjani, and J.H. Kersey. 1983. In vitro cytodestruction of leukemia cells in human bone marrow using a cocktail of monoclonal antibodies. In: Modern Trends in Human Leukemia V R. Neth, R.C. Gallo, M.F. Greaves, M.A.S. Moore, and K. Winkler, eds, Springer-Verlag, New York, pp. 112-116.
- Platt, J., T.W. LeBien, and A.F. Michael. 1983. Stages of renal ontogenesis identified by monoclonal antibodies reactive with lymphohematopoietic differentiation antigens. J. Exp. Med. 157:155-172.
- LeBien, T.W. and J.H. Kersey. 1983. Use of monoclonal antibodies in the study of cell surface antigens on human B lymphocytes. In: Monoclonal Antibodies: Probes for the Study of Autoimmunity and Immunodeficiency B.F. Haynes and G.S. Eisenbarth, eds., Academic Press Inc., pp. 115-129.
- Korsmeyer, S., A. Arnold, A. Bakhshi, J.V. Ravetch, U. Siebenlist, R.A. Hieter, S.O. Sharrow, T.W. LeBien, J.H. Kersey, D.G. Poplack, P. Leder, and T.A. Waldmann. 1983. Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphoblastic leukemias of T-cell and B-cell precursor origins. J. Clin. Invest. 71:301-313.
- Perri, R.T., I. Royston, T.W. LeBien, and N.E. Kay. 1983. Chronic lymphocytic leukemia progenitor cells carry the antigens T65, BA-1 and Ia. Blood 61:871-875.
- LeBien, T.W., J.G. Bradley, D.R. Boue, J.L. Platt, A.F. Michael, and J.H. Kersey. 1984. B cells and kidneys: A "B+CALLA" workshop analysis. In: Leukocyte Typing: Human Leukocyte Differentiation Antigens Detected by Monoclonal Antibodies A. Bernard, L. Boumsell, J. Dausset, C. Milstein, and S. Schlossman, eds., Springer-Verlag, pp. 346-353.
- Kersey, J.H. and T.W. LeBien. 1984. What happened to lineage and leukemia-specific antigens? Implications for therapeutic use of monoclonal antibodies. In: Leukocyte Typing: Human Leukocyte Differentiation Antigens Detected by Monoclonal Antibodies A. Bernard, L. Boumsell, J. Dausset, C. Milstein, and S. Schlossman, eds., Springer-Verlag, pp. 651-656.
- Royston, I., J. Minowada, T. LeBien, G. Pavlov, G. Vosika, C. Bloomfield, and R. Ellison. 1984. Phenotypes of adult acute lymphoblastic leukemia defined by monoclonal antibodies. In: Leukocyte Typing: Leukocyte Differentiation Antigens Detected by Monoclonal Antibodies A. Bernard, L. Boumsell, J. Dausset, C. Milstein, and S. Schlossman, eds., Springer-Verlag, pp. 558-564.
- LeBien, T.W., J.G. Bradley, and B. Koller. 1983. Preliminary structural characterization of the leukocyte cell surface molecule recognized by monoclonal antibody TA-1. J. Immunol. 130:1833-1836.
- Melink, G.B. and T.W. LeBien. 1983. Construction of an antigenic map for human B cell precursors. J. Clin. Immunol. 3:260-267.
- Vallera, D.A., J.H. Kersey, R.R. Quinones, E.D. Zanjani, C.C.B. Soderling, S.M. Azemove, T.W. LeBien, P.C.L. Beverley, R.C. Ash, D.M. Neville, Jr., and R.J. Youle. 1983. Antibody-ricin conjugates: purgative reagents for murine and human allogeneic bone marrow transplantation. In: Recent Advances in Bone Marrow Transplantation R.P. Gale, ed., Alan R. Liss Inc., pp. 209-222.
- Bakhshi, A., A. Arnold, S. Sharrow, T.W. LeBien, J.H. Kersey, D.G. Poplack, P. Leder, T. Waldmann, and S.J. Korsmeyer. 1983. Correlations of cell surface antigen expression and immunoglobulin gene rearrangements in acute lymphocytic leukemia. In: Normal and Neoplastic Hematopoiesis D.W. Golde and P.A. Marks, eds., Alan R. Liss, Inc. In press.
- Vallera, D.A., R.C. Ash, E.D. Zanjani, J.H. Kersey, T.W. LeBien, P.C.L. Beverly, D.M. Neville, and R.J. Youle. 1983. Anti-T cell reagents for human bone marrow transplantation: Ricin linked to three monoclonal antibodies. Science 222:512-515.
- Dowell, B.L., F.L. Turk, M.J. Borowitz, T.W. LeBien, and R.S. Metzgar. 1984. Phylogenetic distribution of a 24,000 dalton human leukemia-associated antigen on platelets and kidney cells. Develop. and Comp. Immunol. 8:187-195.
- Jansen, J., F. Falkenburg, D.E. Stepan, and T.W. LeBien. 1984. Removal of neoplastic cells from autologous bone marrow grafts with monoclonal antibodies. Seminars in Hematol. 21:164-181.
- Neudorf, S.M.L., T.W. LeBien, F. Bollum, and J.H. Kersey. 1984. Double fluorochrome analysis of human bone marrow lymphoid cells using terminal transferase and anti-T cell monoclonal antibodies. Exper. Hematol. 12:69-73.
- Quinones, R.R., R.J. Youle, J.H. Kersey, E.D. Zanjani, S.M. Azemove, C.C.B. Soderling, T.W. LeBien, P.C.L. Beverly, D.M. Neville Jr., and D.A. Vallera. 1984. Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: Effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow. J. Immunol. 132:678-683.
- Stepan, D.E., R.M. Bartholomew, and T.W. LeBien. 1984. In vitro cytodestruction of human leukemic cells using murine monoclonal antibodies and human complement. Blood 63:1120-1124
- Kersey, J., D. Vallera, N. Ramsay, L. Filipovich, R. Stong, T. LeBien, R. Youle, D. Neville, and P. Beverly. 1984. Monoclonal antibodies for purging bone marrow of acute lymphoblastic leukemia or graft versus host producing cells: antibody plus complement or immunotoxins. In: Minimal Residual Disease in Acute Leukemia B. Lowenberg and A. Hagenbeek, eds., Martinus Nijhoff Publishers, pp. 233-239.
- Neudorf, S.M.L., T.W. LeBien, and J.H. Kersey. 1984. Characterization of thymocytes expressing the common acute lymphoblastic leukemia antigen. Leuk. Res. 8:173-179.
- Bloomfield, C.D., K.J. Gajl-Peczalska, G. Frizzera, and T.W. LeBien. 1984. The clinical utility of cell surface markers in malignant lymphoma. In: UT M.D. Anderson Clinical Conferences on Cancer, Vol. 27 R.J. Ford, L.M. Fuller, and F.B. Hagemeister, eds., Raven Press, New York, pp. 263-276.
- Eddy, A., S. Newman, F. Cosio, T. LeBien, and A. Michael. 1984. The distribution of the CR3 receptor on human cells and tissue as revealed by a monoclonal antibody. Clin. Immunol. Immunopathol. 31:371-389.
- Skubitz, K.M., P.R. Craddock, D.J. Weisdorf, J.E. Niedel, T.W. LeBien, J.H. Kersey, R.D. Brunning, J.L. Parkin, P.J. Flynn, and D.E. Hammerschmidt. 1984. Chronic myelogenous leukemia. Development of blast crisis with both lymphoid and myeloid features. J. Amer. Med. Assoc. 250:2957-2960.
- Gregg, S.L., K.J. Gajl-Peczalska, T.W. LeBien, C.D. Bloomfield, R. Brunning, and K. Sagawa. 1984. TPA induction of myeloid differentiation in acute undifferentiated leukemia. Cancer Res. 44:2724-2730.
- LeBien, T.W., J.G. Bradley, R.T. McCormack, and S.J. Pirruccello. 1984. Structural analysis and diagnostic utility of human leukemia membrane molecules. In: Lymphocyte Surface Antigens 1984 E.R. Heise, ed., American Society for Histocompatibility and Immunogenetics, pp. 247-257.
- Sacchi, N., T.W. LeBien, S. Trost, D. Breviario, and F.J. Bollum. 1984. Phorbol/ester-induced changes in human leukemic pre-B lines. Cellular Immunol. 84:65-73.
- LeBien, T.W., D.E. Stepan, R.M. Bartholomew, R.C. Stong, and J.M. Anderson. 1985. Utilization of a colony assay to assess the variables influencing elimination of leukemic cells from human bone marrow with monoclonal antibodies and complement. Blood 65:945-950.
- Bloomfield, C.D., D.C. Arthur, E.G. Levine, G. Frizzera, K.J. Gajl-Peczalska, T.W. LeBien, D.D. Hurd, and B.A. Peterson. 1985. Chromosome abnormalities in malignant lymphoma: biologic and clinical correlations. In: Modern Trends in Human Leukemia VI R. Neth, ed., Springer-Verlag, pp. 145-150.
- Bloomfield, C.D., D.C. Arthur, E.G. Levine, G. Frizzera, K.J. Gajl-Peczalska, T.W. LeBien, D.D. Hurd, and B.A. Peterson. 1985. Banded, chromosome abnormalities in non-Hodgkins lymphoma: Correlations with morphology, immunologic phenotype, and clinical course. In: Malignant Lymphomas and Hodgkin's Disease: Experimental and Therapeutic Advances. S. Cavalli, G. Bonadonna, and M. Rozencweig, eds., Martinus Nijhoff, Hingham, MA, pp. 73-80.
- Kersey, J., D. Vallera, N. Ramsay, A. Filipovich, R. Youle, D. Neville, Jr., R. Stong, and T. LeBien. 1985. Monoclonal antibodies and immunotoxins in bone marrow transplantation: Purging marrow of ALL or GVHD cells with preservation of stem cells. In: Modern Trends in Human Leukemia VI R. Neth, ed., Springer-Verlag, pp. 34-38.
- Ziegler-Heitbrock, H.W.L., H. Rumpold, D. Kraft, C. Wagenpfeil, R. Munker, T. Abo, C.M. Balch, and T.W. LeBien. 1985. Patients with a deficiency of natural killer cell activity lack the VEP13 positive lymphocyte subpopulation. Blood 65:65-70.
- Pirruccello, S.J., and T.W. LeBien. 1985. A structurally novel human B cell surface molecule. In: Leukocyte Typing II, Volume 2 Human B Lymphocytes E.L. Reinherz, B.F. Haynes, L.M. Nadler, and I.D. Bernstein, eds., Springer-Verlag, pp. 227-234.
- LeBien, T.W., J.G. Bradley, J.L. Platt, and S.J. Pirruccello. 1985. Structural analysis of cell surface molecules recognized by leukemic cell/B cell panel antibodies. In: Leukocyte Typing II, Volume 2 Human B Lymphocytes E.L. Reinherz, B.F. Haynes, L.M. Nadler, and I.D. Bernstein, eds., Springer-Verlag, pp. 169-175.
- McCormack, R.T., J.G. Bradley, and T.W. LeBien. 1985. Human neutrophils synthesize different forms of the common acute lymphoblastic leukemia antigen. In: Leukocyte Typing II, Volume 2 Human B Lymphocytes E.L. Reinherz, B.F. Haynes, L.M. Nadler, and I.D. Bernstein, eds., Springer-Verlag, pp. 235-241.
- Ramsay, N., T. LeBien, M. Nesbit, P. McGlave, D. Weisdorf, P. Kenyon, D. Hurd, A. Goldman, T. Kim, J. Kersey. 1985. Autologous bone marrow transplantation for patients with acute lymphoblastic leukemia in second or subsequent remission: results of bone marrow treated with monoclonal antibodies BA-1, BA-2, BA-3 plus complement. Blood 66:508-513.
- Sobol, R.E., I. Royston, T.W. LeBien, J. Minowada, K. Anderson, F.R. Davey, J. Cuttner, C. Schiffer, R.R. Ellison, and C.D. Bloomfield. 1985. Adult acute lymphoblastic leukemia phenotypes defined by monoclonal antibodies. Blood 65:730-735.
- Pirruccello, S.J. and T.W. LeBien. 1985. Monoclonal antibody BA-1 recognizes a novel human leukocyte cell surface sialoglycoprotein complex. J. Immunol. 134:3962-3968.
- LeBien, T.W., S.J. Pirruccello, R.T. McCormack and J.G. Bradley. 1985. P24 and p26 are structurally related cell surface molecules identified by monoclonal antibody BA-2. Molecular Immunol. 22:1185-1194.
- Nesbit, M.E., W.G. Woods, D. Weisdorf, A.H. Filipovich, T.W. LeBien, J.H. Kersey, and N.K.C. Ramsay. 1985. Bone marrow transplantation for acute lymphocytic leukemia. Seminars Oncol. 12:149-159.
- LeBien, T.W., J.M. Anderson, D.A. Vallera, and F.M. Uckun. 1985. Increased efficacy in selective elimination of leukemic cells by a combination of monoclonal antibodies BA-1, BA-2, BA-3 + complement and mafosfamid (ASTA Z 7557). Leuk. Res. 10:139-143.
- LeBien, T.W. and J.H. Kersey. 1985. No evidence for structural or functional identity between p24/CD9 and p21/ras. Leuk. Res. 9:1565-1570.
- Pirruccello, S.J. and T.W. LeBien. 1986. The human B cell-associated antigen CD24 is a single chain sialoglycoprotein. J. Immunol. 136:3779-3784.
- Sobol, R.E., R. Mick, T.W. LeBien, H. Ozer, J. Minowada, K. Anderson, R.R. Ellison, J. Cuttner, A. Morrison, F. Richards, I. Royston, and C.D. Bloomfield. 1986. The reproducibility of acute lymphoblastic leukemia phenotype determinations: evaluation of monoclonal antibody and conventional hematopoietic markers. Leuk. Res. 10:481-485.
- Kersey, J., T. LeBien, D. Vallera, A. Filipovich, P. McGlave, T. Kim, and N. Ramsay. 1986. Allogeneic and autologous marrow transplantation: Ex vivo purging with monoclonal antibody or immunotoxins to remove leukemic cells or to prevent graft versus host disease. In: Minimal Residual Disease in Acute Leukemia 1986 A. Hagenbeek and B. Lowenberg, eds., Martinus Nijhoff Publishers, pp. 275-281.
- McCormack, R.T., R.D. Nelson, and T.W. LeBien. 1986. Structure/function studies of the common acute lymphoblastic leukemia antigen (CALLA/CD10) expressed on human neutrophils. J. Immunol. 137:1075-1082.
- Bodger, M.D. and T.W. LeBien. 1986. The kinetics of terminal deoxynucleotidyl transferase-positive cells in the mixed colony assay. Int. J. Cell Cloning 4:312-319.
- Levine, E.G., D.C. Arthur, K.J. Gajl-Peczalska, T.W. LeBien, B.A. Peterson, D.D. Hurd, and C.D. Bloomfield. 1986. Correlations between immunological phenotype and karyotype in malignant lymphoma. Cancer Res. 46:6481-6488.
- Ramsay, N., M. Nesbit, P. McGlave, D. Weisdorf, D. Hurd, A. Goldman, T. Kim, J. Kersey, W. Woods, and T. LeBien. 1987. Autologous bone marrow transplantation (BMT) for patients with acute lymphoblastic leukemia (ALL) in second or subsequent remission: results of bone marrow treated with monoclonal antibodies BA-1, BA-2, BA-3 and complement using two sequential preparative regimens. In: Recent Advances in Bone Marrow Transplantation, UCLA Symposia on Molecular and Cellular Biology R.P. Gale and R. Champlin, eds., Alan R. Liss, Inc., New York, pp. 751-758.
- Uckun, F.M., T.W. LeBien, K.J. Gajl-Peczalska, J.H. Kersey, D.E. Myers, J.M. Anderson, T.B. Dickson, and D.A. Vallera. 1987. Ex vivo marrow purging in autologous bone marrow transplantation for acute lymphoblastic leukemia: Use of novel colony assays to test the anti-leukemic efficacy of various strategies. In: Recent Advances in Bone Marrow Transplantation, UCLA Symposia on Molecular and Cellular Biology R.P. Gale and R. Champlin, eds., Alan R. Liss, Inc., New York, pp. 759-772.
- Kersey, J.H., D. Weisdorf, M. Nesbit, W. Woods, T. LeBien, P. McGlave, T. Kim, A. Filipovich, D. Vallera, R. Haake, B. Bostrom, D. Hurd, W. Krivit, A. Goldman, and N. Ramsay. 1987. Allogeneic and autologous bone marrow transplantation for acute lymphoblastic leukemia (ALL). In: Recent Advances in Bone Marrow Transplantation, UCLA Symposia on Molecular and Cellular Biology R.P. Gale and R. Champlin, eds., Alan R. Liss, Inc., New York, pp. 55-76.
- Kersey, J.H., J.M. Greenberg, N.K.C. Ramsay, K. Gajl-Peczalska, and T.W. LeBien. 1987. The immune system and lymphoid neoplasia. In: Malignant Lymphoma C.W. Berard, R.F. Dorfman, and N. Kaufman, eds., Williams and Wilkins, pp. 8-17.
- Gonzalez-Sarmiento, R., T.W. LeBien, J.G. Bradley, J.M. Greenberg, J.G. Seidman, S. Ang, and J.H. Kersey. 1987. A human leukemia expressing the gamma gene product of the putative second T cell receptor. J. Clin. Invest. 79:1281-1284.
- Wörmann, B., S.R. Mehta, A.L. Maizel, and T.W. LeBien. 1987. Low molecular weight B cell growth factor induces proliferation of human B cell precursor acute lymphoblastic leukemias. Blood 70:132-138.
- Wörmann, B., J.M. Anderson, Z.D. Ling, and T.W. LeBien. 1987. Structure/function analyses of IL-2 binding proteins on B cell precursor acute lymphoblastic leukemias. Leukemia 1:660-666.
- Kersey, J.H., D. Weisdorf, M.E. Nesbit, T.W. LeBien, W.G. Woods, P.B. McGlave, T. Kim, D.A. Vallera, A.I. Goldman, B. Bostrom, D. Hurd, N.K.C. Ramsay. 1987. Comparison of autologous and allogeneic bone marrow transplantation for treatment of high risk refractory acute lymphoblastic leukemia. N. Engl. J. Med. 317:461-467.
- Kersey, J., T. LeBien, N. Ramsay, A. Filipovich, P. McGlave, F. Uckun, B. Blazar, D. Vallera. 1987. Antibodies and immunotoxins for bone marrow purging. Bone Marrow Transplantation 2:47-49 (Suppl).
- Bast, R.C., R.B. Montgomery, A. Haleem J. Kurtzberg, A. Rhinehardt-Clark, D. Leslie, C. Boyer, C. Smith, G. Olsen, A Frankel, D. Ring, S. Ramakrishnan, L. Houston, L, Nadler, J. Ritz, and T. LeBien. 1987. Bone marrow purging with antibody and complement: an American review. Bone Marrow Transplantation 2:58-65 (Suppl).
- McCormack, R.T., R.D. Nelson, D.E. Chenoweth, and T.W. LeBien. 1987. Identification and characterization of a unique subpopulation (CALLA/CD10 negative) of human neutrophils manifesting a heightened chemotactic response to activated complement. Blood 70:1624-1629.
- Saito, H., T. Koyama, K. Georgopoulos, H. Clevers, W. Haser, T. LeBien, S. Tonegawa, and C. Terhorst. 1987. Close linkage of the mouse and human CD3d and g genes suggests a control of their transcription by common regulatory elements. Proc. Natl. Acad. Sci. 84:9131-9134.
- Kay, N.E., N. Bone, and T.W. LeBien. 1987. The effect of CD21 (anti-CR2) monoclonal antibodies on human B cell proliferation, membrane depolarization, and cytoplasmic calcium concentration. In: Leukocyte Typine III - White Cell Differentiation Antigens. A.-J. McMichael, ed., Oxford University Press, Oxford, pp. 443-445.
- Boué, D.R. and T.W. LeBien. 1988. Structural characterization of the human B lymphocyte-restricted differentiation antigen CD22 -- comparison with CD21 (CR2/EBV receptor). J. Immunol. 140:192-199.
- McCormack, R.T., R.D. Nelson, L.D. Solem, and T.W. LeBien. 1988. Decreased expression of the common acute lymphoblastic leukemia antigen (CALLA/CD10) on neutrophils from patients with thermal injury. Brit. J. Haematol. 69:189-195.
- Boué, D.R. and T.W. LeBien. 1988. Expression and structure of CD22 in acute leukemia. Blood 71:1480-1486.
- Hurd, D.D., T.W. LeBien, L.C. Lasky, R.J. Haake, N.K.C. Ramsay, T.H. Kim, E.G. Levine, P.B. McGlave, C.D. Bloomfield, B.A. Peterson, and J.H. Kersey. 1988. Autologous bone marrow transplantation in non-Hodgkin's lymphoma: monoclonal antibodies plus complement for ex vivo marrow treatment. Amer. J. Med. 85:829-834.
- Ramsay, N., T. LeBien, D. Weisdorf, W. Woods, B. Bostrom, M. Nesbit, D. Vallera, F. Uckun, A. Goldman, T. Kim, R. Haake, L. Lasky, and J. Kersey. 1988. Autologous BMT for patients with acute lymphoblastic leukemia. In: Bone Marrow Transplantation - Current Controversies, UCLA Symposium on Molecular and Cellular Biology. R.P. Gale and R. Champlin, eds., Alan R. Liss, Inc., New York. In press.
- Wörmann, B., J.M. Anderson, J.A. Liberty, K. Gajl-Peczalska, R.D. Brunning, T.L. Silberman, D.C. Arthur, and T.W. LeBien. 1989. Establishment of a leukemic cell model for studying human pre-B to B cell differentation. J. Immunol. 142:110-117.
- LeBien, T.W. and R.T. McCormack. 1989. The common acute lymphoblastic leukemia antigen (CD10) - Emancipation from a functional enigma. Blood 73:625-635.
- LeBien, T.W. 1989. Some thoughts on normal and leukemic human B cell precursors. In: Acute Lymphoblastic Leukemia, UCLA Symposium on Molecular and Cellular Biology, New Series, Volume 108. R.P. Gale and D. Hoelzer, eds., Alan R. Liss, Inc., New York, pp 29-34.
- Wörmann, B., T.G. Gesner, R.A. Mufson, and T.W. LeBien. 1989. Proliferative effect of interleukin-3 on normal and leukemic human B cell precursors. Leukemia 3:399-404.
- Nong, Y.-H, E. Remold-O'Donnell, T.W. LeBien, and H.G. Remold. 1989. A monoclonal antibody to sialophorin (CD43) induces homotypic adhesion and activation of human monocytes. J. Exp. Med. 170:259-267.
- LeBien, T.W. 1989. Growing human B cell precursors: the continuing challenge. Immunol. Today 10:296-298.
- LeBien, T.W. and J.G. Villablanca. 1990. Ontogeny of normal human B-cell and T-cell precursors and its relation to leukemogenesis. In: Childhood Lymphoblastic Leukemia: Biology of the Lymphoblast. C. Pochedly and C. Civin, eds., W.B. Saunders Co., Philadelphia, pp. 835-847.
- LeBien, T.W., B. Wörmann, J.G. Villablanca, C.-L. Law, L.M. Steinberg, V.O. Shah, and M.R. Loken. 1990. Multiparameter flow cytometric analysis of human fetal bone marrow B cells. Leukemia 4:354-358.
- Villablanca, J.G., J.M. Anderson, M. Moseley, C.-L. Law, R.L. Elstrom, and T.W. LeBien. 1990. Differentiation of normal human pre-B cells in vitro. J. Exp. Med. 172:325-334.
- Mehmet, H., M. Larkin, P.W. Tang, T.W. LeBien, and T. Feizi. 1990. Monoclonal antibody BA-1 to the human B lymphocyte marker CD24 recognizes a sialic acid (N-acetylneuraminic acid) dependent epitope in multivalent display on peptide. Clin. Exp. Immunol. 81:489-495.
- LeBien, T.W., R.L. Elstrom, M. Moseley, J.H. Kersey, and F. Griesinger. 1990. Analysis of Ig and TCR gene rearrangements in human fetal bone marrow B lineage cells. Blood 76:1196-1200.
- LeBien, T.W. 1990. Developmental regulation of normal and leukemic human B cell precursors. In: The Biology of Hematopoiesis. Progress in Clinical and Biological Research Vol. 352. N. Dainiak, E.P. Cronkite, R. McCaffrey, R.K. Shadduck, eds. Wiley-Liss, New York, pp. 417-422.
- Law, C.-L., B. Wörmann, and T.W. LeBien. 1990. Analysis of expression and function of CD40 on normal and leukemic human B cell precursors. Leukemia 4:732-738.
- Martin, D., R. Huang, T.W. LeBien, and B. Van Ness. 1991. Induced rearrangement of kappa genes in the BLIN-1 human pre-B cell line correlates with germline J-Ck and Vk transcription. J. Exp. Med. 173:639-645.
- Law, C.-L., R.J. Armitage, J.G. Villablanca, and T.W. LeBien. 1991. Expression of IL-4 receptors on early human B lineage cells. Blood 78:703-710.
- Weisdorf, D.J., R. Haake, W.J. Miller, P.B. McGlave, T.W. LeBien, D.A. Vallera, L.C. Lasky, T.H. Kim, B.A. Peterson, N.K.C. Ramsay, J.H. Kersey, and D.D. Hurd. 1991. Autologous bone marrow transplantation for progressive non-Hodgkins lymphoma: Clinical impact of immunophenotype and in vitro purging, Bone Marrow Transplantation 8:135-142.
- Wolf, M.L., J. Buckley, A. Goldfarb, C.-L. Law, and T.W. LeBien. 1991. Development of a bone marrow culture for maintenance and growth of normal human B cell precursors. J. Immunol. 147:3324-3330.
- Davis, I.D., T.W. LeBien, B.J. Lindman, and J.L. Platt. 1991. Biochemical and histochemical characterization of a murine tubular antigen. J. Amer. Soc. Nephrol. 1:1153-1161.
- Lassoued, K., C.A. Nuñez, L. Billips, H. Kubagawa, R.C. Monteiro, T.W. LeBien, and M.D. Cooper. 1993. Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell 73:73-86.
- Dittel, B.N., J.B. McCarthy, E.A. Wayner, and T.W. LeBien. 1993. Regulation of human B cell precursor adhesion to bone marrow stromal cells by cytokines which exert opposing effects on the expression of vascular cell adhesion molecule-1. Blood 81:2272-2282.
- Wolf, M.L., W.-K. Weng, K. Stieglbauer, N. Shah, and T.W. LeBien. 1993. Functional effect of IL-7 increased CD19 expression on human B-cell precursors. J. Immunol. 151:138-148.
- Pauza, M.E., J.A. Rehmann, and T.W. LeBien. 1993. Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: human B cells can simultaneously express cell surface kappa and lambda light chains. J. Exp. Med. 178:139-149.
- Rehmann, J.A., and T.W. LeBien. 1994. Transforming growth factor beta regulates human pre-B cell differentiation. Inter. Immunol. 6:315-322.
- LeBien, T.W. 1994. Lymphocyte ontogeny and homing receptors. In: Williams Hematology, 5th edition. E. Beutler, M.A. Lichtman, B.S. Coller, and T.J. Kipps, eds., McGraw-Hill, Inc., pp. 921-929.
- Larson, A.W., and T.W. LeBien. 1994. Cross-linking CD40 on human B cell precursors inhibits or enhances growth depending on the stage of development and the interleukin co-stimulus. J. Immunol. 153:584-594.
- Weng, W.-K., L. Jarvis, and T.W. LeBien. 1994. Signalling through CD19 activates Vav/mitogen activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. J. Biol. Chem. 269:32514-32521.
- LeBien, T.W. 1995. CD24 Workshop Panel Report. In: Leucocyte Typing V, White Cell Differentiation Antigens, S.F.Schlossman et al., eds., Oxford University Press, pp. 539-541.
- Dittel, B.N., and T.W. LeBien. 1995. Identification of known and novel adhesion molecules on human bone marrow stromal cells. In: Leucocyte Typing V, White Cell Differentiation Antigens, S.F.Schlossman et al., eds., Oxford University Press, pp. 1688-1689.
- Dittel, B.N., and T.W. LeBien. 1995. Amplification of B cell precursor/bone marrow stromal cell adhesion with antibodies to CD44. In: Leucocyte Typing V, White Cell Differentiation Antigens,, S.F.Schlossman et al., eds., Oxford University Press, pp. 1733-1735.
- Rehmann, J.A., and T.W. LeBien. 1995. Expression and function of epitopes recognized by the unknown B cell mAb panel during early human B cell development. In: Leucocyte Typing V, White Cell Differentiation Antigens, S.F.Schlossman et al., eds., Oxford University Press, pp. 626-628.
- Fang, W., J.J. Rivard, J.A. Ganser, T.W. LeBien, K.A. Nath, D.L. Mueller, and T.W. Behrens. 1995. Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli. J. Immunol. 155:66-75.
- Dittel, B.N., and T.W. LeBien. 1995. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34. J. Immunol. 154:58-67.
- Billadeau, D., D.F. Jelinek, N. Shah, T.W. LeBien, and B. Van Ness. 1995. Introduction of an activated N-ras oncogene alters the growth characteristics of the IL-6 dependent myeloma cell line ANBL6. Cancer Res. 55:3640-3646.
- Pribyl, J.R., B.N. Dittel, and T.W. LeBien. 1995. In vitro studies of human B lymphopoiesis. In: Immunoglobulin Gene Expression in Development and Disease, P. Casali and L.E. Silberstein, eds., Annals of the New York Academy of Sciences 764:9-18.
- Dittel, B.N., and T.W. LeBien. 1995. Reduced expression of vascular cell adhesion molecule-1 (VCAM-1/CD106) on bone marrow stromal cells isolated from marrow transplant recipients correlates with a reduced capacity to support human B lymphopoiesis in vitro. Blood 86:2833-2841.
- Jarvis, L.J., and T.W. LeBien. 1995. Stimulation of human bone marrow stromal cell tyrosine kinases and IL-6 production by contact with B lymphocytes. J. Immunol. 155:2359-2368.
- LeBien, T.W. 1996. Lymphopoiesis. In: Leukemia, sixth edition. E.S. Henderson, T.A. Lister, and M.F. Greaves, eds., W.B. Saunders Company, Philadelphia, pp. 65-82.
- LeBien, T.W. 1996. A little bit of CD history. Transfusion 36:197-199.
- Pribyl, J.A.R, and T.W. LeBien. 1996. IL-7 independent development of human B cells. Proc. Natl. Acad. Sci. USA 93:10348-10353.
- Pribyl, J.A.R., N. Shah, B.N. Dittel, and T.W. LeBien. 1997. Methods for purification and growth of human B cell precursors in bone marrow stromal cell-dependent cultures. In: The Immunology Methods Manual I. Lefkovits, ed., Academic Press Inc., pp. 902-923.
- Billadeau, D., P. Liu, N. Shah, T.W. LeBien, D. Jelinek, and B. Van Ness. 1997. Activating mutations in the N- and K-ras oncogene differentially affect the growth properties of the IL-6 dependent myeloma cell line ANBL6. Cancer Res. 57: 2268-2275.
- Jarvis, L.J., J.E. Maguire, and T.W. LeBien. 1997. Contact between human bone marrow stromal cells and B lymphocytes enhances adhesion-independent tyrosine phosphorylation of focal adhesion kinase, paxillin, and ERK-2 in stromal cells. Blood 90: 1626-1635.
- Weng, W.-K., N. Shah, D. O'Brien, B. Van Ness, and T.W. LeBien. 1997. Differential induction of DNA-binding activities following CD19 cross-linking in human B-lineage cells. J. Immunol. 159:5502-5508.
- Jarvis, L.J., and T.W. LeBien. 1998. Cytokine and stromal influences on early B cell development. In: Molecular Biology of B-Cell and T-Cell Development. J.G. Monroe and E. Rothenberg, eds., Humana Press, pp. 231-251.
- LeBien, T.W. 1998. B lymphopoiesis in mouse and man. Current Opin. Immunol. 10: 188-195.
- Shah, N., L. Oseth, and T.W. LeBien. 1998. Development of a model for evaluating the interaction between human pre-B acute lymphoblastic leukemic cells and the bone marrow stromal cell microenvironment. Blood 92:3817-3828.
- Kurosaka, D., T.W. LeBien, and J.A.R. Pribyl. 1999. Comparative studies of different stromal cell microenvironments in support of human B cell development. Exper. Hematol. 27:1271-1281.
- Rao, S.P., J.M. Riggs, D.F. Friedman, M.S. Scully, T.W. LeBien, and L.E. Silberstein. 1999. Biased VH gene usage in early human B-lineage cells: evidence for preferential Ig gene rearrangement in the absence of selection. J. Immunol. 163:2732-2740.
- LeBien, T.W., and F.E. Bertrand. 2000. Lymphocyte Ontogeny. In: Williams’ Hematology Sixth Edition. E. Beutler et al, eds. McGraw-Hill, pp. 927-936.
- LeBien, T.W.2000. Fates of human B-cell precursors. Blood 96:9-23.
- Bertrand, F.E., C.E. Eckfeldt, J.R. Fink, A.S. Lysholm, J.A.R. Pribyl, N. Shah, and T.W. LeBien. 2000. Microenvironmental influences on human B-cell development. Immunol. Rev. 175:175-186.
- Bertrand, F.E., C.E. Eckfeldt, A.S. Lysholm, and T.W. LeBien. 2000. Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells. Leukemia 14:2095-2102.
- Fink J. and T.W. LeBien. 2001. Novel expression of cyclin-dependent kinase inhibitors in human B cell precursors. Exper. Hematol. 29:490-498.
- Shah, N., L. Oseth, H. Tran, B. Hirsch, and T.W. LeBien. 2001. Clonal variation in the B-lineage acute lymphoblastic leukemia response to multiple cytokines and bone marrow stromal cells. Cancer Res. 61:5268-5274.
- Bertrand, F.E., C. Vogtenhuber, N. Shah, and T.W. LeBien. 2001. Pro-B cell to pre-B cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/AF4 fusion protein. Blood 98:3398-3405.
- Campana, D. and T.W. LeBien. 2002. Lymphopoiesis. In: Leukemia, seventh edition, E.S. Henderson, T.A. Lister and M.F. Graeves, eds., Saunders, Philadelphia, pp. 47-67.
- Karasuyama H., T.W. LeBien, M.D. Copper, and E.A. Clark. 2002. CD179 workshop report. In: Leukocyte Typing VII: White Cell Differentiation Antigens. D. Mason et al., eds., Oxford University Press, pp.112-115.
- LeBien, T.W. Arginine: an unusual dietary requirement of pre-B lympocytes? 2002. J. Clin. Invest. 110:1411-1413.
- Bertrand, F.E., J. Spengeman, N. Shah, and T.W. LeBien. 2003. B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression. Leukemia 17:2454-2459.
- Burrows, P.D., T.W. LeBien, Z Zhang, and M.D. Cooper. 2004. The development of human B lymphocytes. In: Molecular Biology of B Cells, F.W. Alt, T. Honjo and M. Neuberger eds. Academic Elsevier Press, pp. 141-154.
- Shah, N., R.J. Asch, A.S. Lysholm, and T.W. LeBien. 2004. Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor. Blood 104:2873-2878.
- Johnson, S.E., N. Shah, A. Panoskaltsis-Mortari, and T.W. LeBien. 2005. Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells. J. Immunol. 175:7325-7331.
- LeBien, T.W. 2006. Lymphopoiesis: In: Williams Hematology, Seventh Edition. M.A. Lichtman, E. Beutler, T.J. Kipps, U. Seligsohn, K. Kaushansky, and J.T. Prchal eds. McGraw-Hill Medical, pp. 1039-1049.
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