Anthony Killeen, M.D., Ph.D.

Associate Professor
Director of Clinical Laboratories

Educational Background

• University College, Galway, Ireland (1980), B.Sc. with Honors (Biochemistry)
• University College, Galway, Ireland (1983), M.D.
• University of Minnesota (1990), Ph.D. (Pathobiology)
• Hennepin County Medical Center and Mount Sinai Hospital (1985), Residency (Internal Medicine)
• University of Minnesota (1991), Residency/Fellowship (Pathology)

Professional Background

• Jul 1992-Aug 1993: Assistant Professor, Clinical Chemistry Section, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
• Sep 1993-Mar 2000: Assistant Professor, Department of Pathology, University of Michigan Medical School
• Mar 2000-Aug 2002: Clinical Associate Professor, Department of Pathology, University of Michigan Medical School
• Aug 2002-present: Associate Professor, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

Certifications

• American Board of Pathology (Clinical and Chemical Pathology)
• American Board of Medical Genetics (Clinical Molecular Genetics)
• American Board for Clinical Chemistry (Molecular Diagnostics)

Publications

Books

• Principles of Molecular Pathology. Anthony A. Killeen. Totowa, NJ: Humana Press, 2003, 344 pp. ISBN 1-58829-085-9, 2^nd edition in Preparation

Peer-Reviewed Articles

• Killeen AA, Laboratory sanctions for proficiency testing sample referral and result communication: a review of actions from 1993-2006, Arch Pathol Lab Med 2009, 133(6):979-82
• Miller WG, Myers GL, Ashwood ER, Killeen AA, Wang E, Ehlers GW, Hassemer D, Lo SF, Seccombe D, Siekmann L, Thienpont LM, Toth A: State of the art in trueness and interlaboratory harmonization for 10 analytes in general clinical chemistry, Arch Pathol Lab Med 2008, 132(5):838-46
• Killeen AA, Ossina N, McGlennen RC, Minnerath S, Borgos J, Alexandrov V, Sarvazyan A: Protein self-organization patterns in dried serum reveal changes in B-cell disorders, Mol Diagn Ther 2006, 10:371-380
• Steele BW, Wang E, Palmer-Toy DE, Killeen AA, Elin RJ, Klee GG: Total long-term within-laboratory precision of cortisol, ferritin, thyroxine, free thyroxine, and thyroid-stimulating hormone assays based on a College of American Pathologists fresh frozen serum study: do available methods meet medical needs for precision?, Arch Pathol Lab Med 2005, 129:318-322
• Miller WG, Myers GL, Ashwood ER, Killeen AA, Wang E, Thienpont LM, Siekmann L: Creatinine measurement: state of the art in accuracy and interlaboratory harmonization, Arch Pathol Lab Med 2005, 129:297-304
• Klee GG, Killeen AA: College of American Pathologists 2003 fresh frozen serum proficiency testing studies, Arch Pathol Lab Med 2005, 129:292-293
• Schmidt MA, Chakrabarti AK, Kehrer C, Pfeninnger D, Brook RD, Kaciroti N, Duvernoy C, Killeen AA, Rajagopalan S: Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease, Vasc Med 2003, 8:177-183
• Moser MJ, Marshall DJ, Grenier JK, Kieffer CD, Killeen AA, Ptacin JL, Richmond CS, Roesch EB, Scherrer CW, Sherrill CB, Van Hout CV, Zanton SJ, Prudent JR: Exploiting the enzymatic recognition of an unnatural base pair to develop a universal genetic analysis system, Clin Chem 2003, 49:407-414
• Killeen AA, Breneman JW, 3rd, Carillo AR, Ugozzoli LA, Lowery JD, Liu J, Hixson CS: Linked linear amplification for simultaneous analysis of the two most common hemochromatosis mutations, Clin Chem 2003, 49:1050-1057

For a complete list of Dr. Killeen's publications, please see the National Library of Medicine's PubMed Search.

Invited Lectures

• Killeen AA and Miller GW: “Calibration, calibration verification, analytical measurement range, and clinically reportable range”. College of American Pathologists Audio-Conference, recorded February, 2008 (for delivery on CAP website).
• “Chronic Kidney Disease: Clinical and Laboratory Considerations”. Beckman-Coulter Workshop at AACC National Meeting, San Diego, CA, July 2007.
• “Get up to Speed in Molecular Diagnostics”. Washington G2 Conference, Tampa, FL, Feb 2007.
• “Chronic Kidney Disease” Workshop at CAP Annual meetings 2005, 2006
• “Introduction to Molecular Diagnostics” workshop. William Beaumont Seminar, Royal Oak, Michigan. 2002, 2003, 2005. Co-taught with Dr. Domnita Crisan.
• “Introduction to Molecular Diagnostics”. American Association for Clinical Chemistry. All-day Workshop at National Meeting, Chicago, 2001, 2002, 2003. Co-taught with Dr. Domnita Crisan.
• “Genetics of Cardiovascular Diseases”. Michigan State Genetics Symposium (Wayne State University), May, 2001.
• “Implementing New Technology in the Clinical Laboratory”. ASCP/CAP Annual Meeting, San Diego, CA, October, 2000.
• “Advances in Nucleic Acid Quantification”. Spring ASCP/CAP Meetings, Boston, MA, April 2000.
• “Genetics of Cardiovascular Disease”. William Beaumont Annual DNA Symposium, March, 1999.
• “The Congenital Adrenal Hyperplasias”. XXth World Congress of Pathology, September, 1999 (Sao Paulo, Brazil).
• “Advances in Nucleic Acid Quantification”. Fall ASCP/CAP Meetings, New Orleans, LA, September, 1999.
• “Molecular Pathology of Congenital Adrenal Hyperplasia”. Promega, Inc., Madison, WI, October 11, 1999.
• "Genetics of the Congenital Adrenal Hyperplasias”. San Diego Conference on Nucleic Acids, San Diego, CA, November, 1999.
• “Basic Genetics”. Lecture to the Michigan Association of Blood Banks, March, 1998.
• “Molecular and Biochemical Genetics of Congenital Adrenal Hyperplasia”. Association for Molecular Pathology Annual Meeting, Crystal City, VA, November, 1998
• “The Michigan Genetic Privacy Bill”. Michigan Molecular Diagnostics Forum, June, 1997.
• “Genetics of Alzheimer’s Disease”. Association of Medical Laboratory Immunologists National Meeting, San Francisco, July, 1997.
• “Congenital Adrenal Hyperplasia: Clinical, Biochemical, and Molecular Aspects”. Fifth Annual Symposium on Molecular Pathology, William Beaumont Hospital, Royal Oak, MI, March, 1996.
• “Molecular Biology applications in Pathology”. Ohio Society for Clinical Laboratory Sciences Annual Meeting, Toledo, OH, April, 1996.
• “Using the Net in Laboratory Medicine”. Academy of Clinical Laboratory Scientists and Pathologists Annual Meeting. Roundtable Discussion, St. Louis, MO, June, 1996.
• “Diagnostic Molecular Pathology”. Midwest Clinical Ligand Assay Society, June, 1996.
• “Applications of PCR and LCR in the Clinical Laboratory”. Michigan Society of Clinical Laboratory Science, Kalamazoo, MI January, 1995.
• “Sherlock Holmes meets DNA”. (Forensic applications of DNA testing). University of Michigan Medical Center Community Relations Public Talks (with 2 other speakers), Ann Arbor, MI, April, 1995.
• “Diagnostic Molecular Biology: PCR in the Clinical Laboratory”. Midwest Clinical Ligand Assay Society, Livonia, MI, April, 1995.
• "Practical Applications of Molecular Diagnostics in Pathology", St. Joseph's Hospital, Ann Arbor, March, 1994.
• "Introduction to DNA" and "Genetic Disorders". M-Labs Second Symposium. Consisted of two lectures to practicing pathologists from community hospitals. University of Michigan, April, 1994.
• "DNA, What Is It, and Why Should I Care?". Current Topics in Blood Banking, 21st Annual Symposium, University of Michigan, June, 1994.
• "Applications of Molecular Diagnostics in Clinical Medicine". Central Michigan Community Hospital, Mt. Pleasant, Michigan, September, 1994.
• "Applications of DNA Diagnostics in the Clinical Laboratory". Clinical Laboratory Society, Toledo, Ohio.
• "Molecular Diagnostics: Trends and Applications". Michigan Society of Pathologists Meeting, University of Michigan, Ann Arbor, December, 1994.
• "Molecular Genetics of Steroid 21-Hydroxylase Deficiency", Department of Pathology, University of Michigan, Ann Arbor, Michigan, March, 1993
• "Selected Applications of Molecular Diagnostics in the Clinical Laboratory", American Association of Clinical Chemistry, Midwest and Chicago Sectional Meeting, Chicago, Illinois, May, 1993.
• "Molecular Diagnostics in Selected Hematological Diseases”. American Association of Clinical Chemistry, Midwest Sectional Meeting, Chicago, Illinois, May 1993.
• "Biochemistry in Medical Practice", inaugural address to Biochemical Society, University College, Galway, Ireland, November, 1991.
• "A Mutation Giving Rise to Congenital Adrenal Hyperplasia", Mayo Clinic/University of Minnesota Clinical Chemistry Exchange Meeting, Minneapolis, Minnesota, Spring, 1990.