Stephen C. Jameson, Ph.D.

Associate Professor
612-625-1496
james024@umn.edu

Educational Background

• Bristol University, England (1984), B.Sc. (Cellular Pathology)
• Cambridge University, England (1988), Ph.D. (Immunology)
• Scripps Clinic and Research Foundation, CA (1990), Postdoctoral Fellowship (Immunology)
• University of Washington, Dr. Michael J.Bevan (1995) Senior Fellow (Immunology)

Professional Background

• Assistant Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 1995 - 2001
• Associate Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 2001 - present

Professional Honors

• Studentship, Medical Research Council, 1984 - 1987
• Fellowship, Cancer Research Institute, 1989 - 1991
• Special Fellowship, The Leukemia Society of America, 1993 - 1996
• Junior Faculty Research Award, American Cancer Society, 1996 - 1999

Professional Memberships

• University of Minnesota Cancer Center, 1996 - present

Publications

• Kaye, J., M.-L Hsu, M.E. Sauron, S.C. Jameson, N.R.J. Gascoigne and S.M. Hedrick. (1989) Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341:746.
• Jameson, S.C., J. Kaye and N.R.J. Gascoigne. (1990) A T cell receptor Va region selectively expressed in CD4+ cells. J. Immunol. 145:1324-1331.
• Gahm, S.-J., B.J. Fowlkes, S.C. Jameson, N.R.J. Gascoigne, O. Kanagawa, R. H. Schwartz and L. A. Matis. (1991) Profound alteration in an ab T cell antigen receptor repertoire due to polymorphism in the first complementarity determining region of the b chain. Proc. Nat. Acad. Sci. 88:10267-10271
• Jameson, S.C., P.B. Nakajima, J.L.Brooks, W.Heath, O. Kanagawa, and N.R.J. Gascoigne. (1991) The T cell receptor Va11 gene family. Analysis of allelic sequence polymorphism and demonstration of Ja-region dependent recognition by allele-specific antibodies. J. Immunol. 147:3185-3193.
• Attaya, M., S. Jameson, C.K. Martinez, E. Hermel, C. Aldrich, J. Forman, K. Fischer Lindahl, M.J. Bevan and J.J. Monaco. (1992) Ham-2 corrects the class I antigen processing defect in RMA-S cells. Nature. 355:647-649.
• Jameson, S.C., W.D. Tope, E.M. Tredgett, J.M. Windle, A.G. Diamond and J.C. Howard. (1992) Cloning and expression of class I MHC genes of the rat. J. Exp. Med. 175:1749-1757
• Jameson, S.C. and M.J. Bevan. (1992) Dissection of MHC and TCR contact residues in a Kb restricted ovalbumin peptide and an assessment of the predictive power of MHC binding motifs. Eur. J. Immunol. 22:2663-2667
• Bluestone, J.A., S. Jameson, S. Miller and R. Dick II. (1992) Peptide-induced conformational changes in class I heavy chain alter major histocompatibility complex recognition. J. Exp. Med. 176:1757-1761
• Jameson, S.C., F.R. Carbone and M.J. Bevan. (1993) Clone-specific T cell receptor antagonists of major histocompatibility complex class I restricted cytotoxic T cells. J. Exp. Med. 177:1541-1550
• Wipke, B.T.,S.C. Jameson, M.J. Bevan and E.G. Pamer. (1993) Variable binding affinities of listeriolysin O peptides for the H-2Kd class I molecule. Eur. J. Immunol. 23:2005-2010
• Hogquist, K.A., S.C. Jameson, W.R. Heath, J.L. Howard, M.J. Bevan and F.R. Carbone. (1994) T cell receptor antagonist peptides induce positive selection. Cell. 76:17-27
• Vukmanovic S., S.C. Jameson and M.J. Bevan. (1994) A thymic epithelial cell line induces both positive and negative selection in the thymus. Int. Immunol. 6:239-246
• Dillon, S.R., S.C. Jameson and P.J. Fink. (1994) Vb5+ T cell receptors skew toward OVA + H-2Kb recognition. J. Immunol. 152:1790-1801
• Hogquist, K.A., S.C. Jameson and M.J. Bevan. (1994) The ligand for positive selection of T lymphocytes in the thymus. Curr. Op. Immunol. 6:273-278
• Dick L.R., C. Aldrich, S.C. Jameson, C.R. Moomaw, B.C. Pramanik, C.K. Doyle, G.N. DeMartino, M.J. Bevan, J.M. Forman and C.A. Slaughter. (1994) Proteolytic processing of ovalbumin and b-galactosidase by the proteasome to yield antigenic peptides. J. Immunol. 152:3884-3894
• Bevan, M.J., K.A. Hogquist and S.C. Jameson. (1994) Selecting the T cell receptor repertoire. Science. 264:796-797
• Jameson, S.C., K.A. Hogquist and M.J. Bevan. (1994) Specificity and flexibility in thymic selection. Nature. 369:750-752
• Jameson, S.C. and M.J. Bevan. (1995) T cell receptor antagonists and partial agonists. Immunity. 2:1-11
• Jameson, S.C., K.A. Hogquist and M.J. Bevan. (1995) Positive Selection of Thymocytes. Annu. Rev. Immunol. 13:93-126
• Hogquist, K.A., S.C. Jameson and M.J. Bevan. (1995) Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells. Immunity: 3:79-86
• Alam, S.M., P.J. Travers, J.L. Wung, W. Nasholds, S. Redpath, S.C. Jameson and N.R.J. Gascoigne. (1996) T cell receptor affinity and thymocyte positive selection. Nature. 381:616-620
• Dyall, R., D.H. Fremont, S.C.Jameson and J. NikoliM-ZugiM. (1996) Antigen presentation and positive selection by MHC class I variants: a role of MHC/peptide conformation. J.Exp. Med. 184:253-258
• Hogquist, K.A., A.J. Tomlinson, W.C. Kieper, M.A. McGargill, S. Naylor, and S.C. Jameson. (1997) Identification of a naturally occurring ligand for positive selection. Immunity. 6:389-399
• Naylor, S., Q. Ji, K.L. Johnson, A.J. Tomlinson, W.C. Kieper, S.C. Jameson (1998) Enhanced sensitivity for sequence determination of major histocompatibility complex class I peptides by membrane preconcentration capillary electrophoresis-microspray-tandem mass spectrometry. Electrophoresis 19:2207-2212
• Davey, G.M., S.L. Schober, B.T. Endrizzi, A.K. Dutcher, S.C. Jameson and K. A. Hogquist (1998) Pre-selection thymocytes are more sensitive to TCR stimulation than mature T cells. J.Exp.Med. 188:1867-1874
• Jameson, S.C. (1998) T cell receptor antagonism in vivo, at last. Proc. Natl. Acad. Sci. 95:14001-14002
• Alam, S.M., G.M. Davies, C.M. Lin, T. Zal, W. Nasholds, S.C. Jameson, K.A. Hogquist, N.R.J. Gascoigne, and P.J. Travers. (1999) Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity 10:227-237.
• Daniels, M.A., S.L. Schober, K.A. Hogquist and S. C. Jameson. (1999) Cutting Edge: A test of the dominant negative signal model for TCR antagonism. J. Immunol. 162:3761-3764
• Schober, S.L., C. T. Kuo, K S. Schluns, L. Lefrancois, J. M. Leiden and S. C. Jameson. (1999) Expression of the Transcription Factor LKLF is Regulated by Cytokines and Correlates with Survival of Memory T Cells In Vitro and In Vivo. J. Immunol. 163:3662-3667
• Kieper, W.C. and S. C. Jameson. (1999) Homoestatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands. Proc. Natl. Acad. Sci. (USA). 96:13306-13311
• Daniels, M.A. and S. C. Jameson. (2000) Critical role for CD8 in TCR binding and activation by peptide/MHC multimers. J. Exp.Med. 191:335-345
• Stefanski, H.E., S.C. Jameson and K.A. Hogquist. (2000) Positive selection is limited by available peptide-dependant MHC conformations. J.Immunol. 164: 3519-3526
• Lee P.U., H.R. Churchill, M.A. Daniels, S.C.Jameson and D.M. Kranz. (2000) Role of 2C T cell receptor residues in the binding of self- and allo-major histocompatibility complexes. J. Exp. Med. 191:1355-1364
• Skinner, P.J., M. A. Daniels, C.S. Schmidt, S.C. Jameson, and A.T. Haase. (2000) Cutting Edge: In situ tetramer staining of antigen specific T cells in tissues. J.Immunol. 165:613-617
• Schluns, K.S. W.C. Kieper, S.C. Jameson, and L. Lefrancois. (2000) IL-7 mediates the survival of naive and memory CD8 T cells in vivo Nature Imm. 1:426-432
• Kieper, W. C., M. Prlic, C. S. Schmidt, M.F. Mescher and S.C. Jameson. (2001) IL-12 enhances CD8 T cell homeostatic expansion. J. Immunol. 166:5515-5521.
• Stefanski, H.E., D. Mayerova, S.C.Jameson and K.A. Hogquist. (2001) A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo. J. Immunol. 166:6602-6607
• Rosette, C., G. Werlen, M. A. Daniels, P.O. Holman, S. M. Alam, P.J. Travers, N.R.J. Gascoigne, E. Palmer and S.C. Jameson (2001) The impact of duration versus extent of TCR occupancy on T cell activation: A revision of the kinetic proofreading model. Immunity 15:59-70
• Prlic, M., B. R. Blazar, A. Khoruts, T. Zell and S.C. Jameson. (2001) Homeostatic expansion occurs independently of costimulatory signals J.Immunol. 167:5664-5668
• Daniels, M. A., L. Devine, J. D. Miller, J. M. Moser, A. E. Lukacher, J. D. Altman, P. Kavathas, K. A. Hogquist, and S.C. Jameson. (2001) CD8 binding to MHC Class I molecules is influenced by T cell maturation and glycosylation. Immunity 15:1051-1061
• Prlic, M and S.C. Jameson. (2002) Homeostatic expansion versus antigen-driven proliferation: common ends by different means? Microbes and Infection 4:531-538
• Prlic M, L. Lefrancois, S.C.Jameson. (2002) Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J. Exp. Med. 195:F49-52.
• Jameson SC. (2002) Maintaining the norm: T-Cell homeostasis. Nat. Rev. Immunol. 2:547-556.
• Santori F.R., W.C. Kieper, S.M. Brown, Y. Lu., T.A. Neubert, K.L. Johnson, S. Naylor, S. Vukmanovic, K.A. Hogquist, and S. C. Jameson (2002) Rare, structurally homologous self-peptides promote thymocyte positive selection. Immunity 17:131-142
• McGargill, M.A., D. Mayerova, H.E. Stefanski, B. Koehn, E.A. Parke, S.C. Jameson, A. Panoskaltsis-Mortari, and K.A. Hogquist (2002) A spontaneous CD8 T cell dependent autoimmune disease to an antigen expressed under the K14 promoter. J. Immunol. 169:2141-2147.
• Daniels, M.A., K.A. Hogquist and S.C. Jameson. (2002) Sweet 'n' Sour: The impact of differential glycosylation on T cell responses. Nat. Immunol. 3:903-910
• Moses, C.T., K. M. Thorstenson, S. C. Jameson, and A. Khoruts (2003). Competition for self- ligands restrains homeostatic proliferation of naive CD4 T cells. Proc. Natl. Acad. Sci. (USA) 100:1185-1190
• Prlic M., B. R. Blazar, M. A. Farrar, and S. C. Jameson. In vivo survival and homeostatic proliferation of NK cells. (2003) J.Exp.Med. 197:967-976
• Endrizzi, B.T. and S.C. Jameson. (2003) Differential role for IL-7 in inducing LKLF (KLF-2) expression by naive versus activated T cells. Int.Imm. 15:1341-1348
• Burchill MA, Goetz CA, Prlic M, O'Neil JJ, Harmon IR, Bensinger SJ, Turka LA, Brennan P, Jameson SC, Farrar MA. Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+ CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol. 2003 171:5853-5864.
• Starr TK, Daniels MA, Lucido MM, Jameson SC, Hogquist KA. Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation. J Immunol. 171:4512-20.
• Devine, L., M.E. Hodsdon, M.A. Daniels, S.C.Jameson, P.B. Kavathas (2004). Location of the epitope for an anti-CD8a antibody 53.6.7 which enhances CD8a-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation. Immunol. Lett. 15:123-130
• Mueller, K. L., M. A. Daniels, A. Felthauser, C. Kao, S. C. Jameson, Y. Shimizu. (2004) Cutting Edge: LFA-1 Integrin-Dependent T Cell Adhesion Is Regulated by Both Ag Specificity and Sensitivity. J. Immunol. 173:2222-2226.
• Hagen, K.A., C.T. Moses, E.F. Drasler, K.M. Podetz-Pedersen, S.C. Jameson, A. Khoruts. (2004) A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J. Immunol. 173:3909-3915.
• Sandau, M.M., K.S. Schluns, L. Lefrancois and S.C. Jameson (2004). Cutting Edge: Transpresentation of IL-15 by bone marrow derived cells necessitates expression of IL-15 and IL-15Ra by the same cells. J. Immunol. 173:6537-6541
• Hamilton, S.E., M. Prlic, S.C. Jameson. (2004) Environmental conservation: bystander CD4 T cells keep CD8 memories fresh. Nat. Immunol. 5:873-874
• Baldwin, T.A., K.A. Hogquist and S.C. Jameson (2004) The fourth way? Harnessing aggressive tendencies in the thymus. J. Immunol. 173:6515-6520.
• Starr, T., S.C. Jameson and K.A. Hogquist. (2002) Positive and negative selection of T cells. Ann. Rev. Immunol. 21:139-176
• Jameson, S.C. (2005) T cell homeostasis: Keeping useful T cells alive and live T cells useful. Semin. Immunol. 17:231-237
• Prlic, M., J. Gibbs and S.C. Jameson. (2005) Characteristics of NK Cell Migration Early After Vaccinia Infection. J.Immunol. 175:2152-2157
• Baldwin, T.A., M.M. Sandau, S.C.Jameson and K.A. Hogquist (2005). The timing of TCRa expression critically influences T cell development and selection. J. Exp. Med. 202:111-121