Stephen C. Jameson, Ph.D.

Contact Information Phone: 612-625-1496 Fax: 612-625-2199 Email: james024@umn.edu Address: MMC 334 Mayo 8334 420 Delaware St SE Minneapolis, MN 55455 http://www.jamequist.umn.edu/

Professor

Research Interests

My lab is interested in the factors which regulate survival and activation of mature T cells. T cells require interactions with self peptide/MHC molecules and with cytokines to develop in the thymus and it is becoming clear that similar interactions are also important in supporting proper homeostasis of the mature T cell pool. In fact, in lymphopenic animals (where there is a deficit in normal T cell numbers), T cells respond to self peptide/MHC ligands and certain cytokines through proliferation and differentiation from naïve into memory T cells. These finding raise the question of how mature T cells control their response to self peptide/MHC so they don’t become overtly autoreactive. We’re characterizing the way in which mature and immature T cells perceive self ligands (and other ligands which bind the TCR with low affinity), and how these signals, together with cytokine signals, influences T cell differentiation and survival. One component of this work is to study a transcription factor, LKLF (KLF-2) which is essential for mature T cell survival. Another aspect is to study how both the TCR and the coreceptor CD8 co-operate in recognition of MHC ligands, using Class I MHC tetramers. We're also testing how competition between T cell subsets (and with NK cells) influences the composition of the lymphoid pool. Finally, we’re interested in how glycosylation influences T cell survival and sensitivity.

Educational Background

• Bristol University, England (1984), B.Sc. (Cellular Pathology)
• Cambridge University, England (1988), Ph.D. (Immunology)
• Scripps Clinic and Research Foundation, CA (1990), Postdoctoral Fellowship (Immunology)
• University of Washington, Dr. Michael J.Bevan (1995) Senior Fellow (Immunology)

Professional Background

• Assistant Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 1995 - 2001
• Associate Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 2001 - present

Professional Honors

• Studentship, Medical Research Council, 1984 - 1987
• Fellowship, Cancer Research Institute, 1989 - 1991
• Special Fellowship, The Leukemia Society of America, 1993 - 1996
• Junior Faculty Research Award, American Cancer Society, 1996 - 1999

Professional Memberships

• University of Minnesota Cancer Center, 1996 - present

Publications

• Wang L, Jameson SC, Hogquist KA. Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol. 2009 Nov 1;183(9):5548-53.
• Takada K, Jameson SC. Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels. J Exp Med. 2009 Sep 28;206(10):2253-69.
• Weinreich MA, Takada K, Skon C, Reiner SL, Jameson SC, Hogquist KA. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 2009 Jul 17;31(1):122-30.
• Johnson LD, Jameson SC. Immunology. A chronic need for IL-21.
  Science. 2009 Jun 19;324(5934):1525-6.
• Chu HH, Moon JJ, Takada K, Pepper M, Molitor JA, Schacker TW, Hogquist KA, Jameson SC, Jenkins MK. Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11241-5.
• Xiao Z, Casey KA, Jameson SC, Curtsinger JM, Mescher MF. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol. 2009 Mar 1;182(5):2786-94.
• Hamilton SE, Jameson SC. The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18484-9.
• Wang L, Bursch LS, Kissenpfennig A, Malissen B, Jameson SC, Hogquist KA. Langerin expressing cells promote skin immune responses under defined conditions. J Immunol. 2008 Apr 1;180(7):4722-7.
• Martin AL, Schwartz MD, Jameson SC, Shimizu Y. Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase. J Immunol. 2008 Feb 15;180(4):2081-8.
• Xiao Z, Mescher MF, Jameson SC. Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J Exp Med. 2007 Oct 29;204(11):2667-77.
• Hamilton SE, Jameson SC. CD8(+) T cell differentiation: choosing a path through T-bet. Immunity. 2007 Aug;27(2):180-2.
• Moon JJ, Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity. 2007 Aug;27(2):203-13.
• Sandau MM, Winstead CJ, Jameson SC. IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells. J Immunol. 2007 Jul 1;179(1):120-5.
• Xiao Z, Curtsinger JM, Prlic M, Jameson SC, Mescher MF. The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses. Int Immunol. 2007 Jun;19(6):733-43.
• Carlson CM, Endrizzi BT, Wu J, Ding X, Weinreich MA, Walsh ER, Wani MA, Lingrel JB, Hogquist KA, Jameson SC. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature. 2006 Jul 20;442(7100):299-302.
• Jameson SC. T cells climb on board Blimp-1. Trends Immunol. 2006 Aug;27(8):349-51.
• Kao C, Sandau MM, Daniels MA, Jameson SC. The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development. J Immunol. 2006 Jun 15;176(12):7421-30.
• Hamilton SE, Wolkers MC, Schoenberger SP, Jameson SC. The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells. Nat Immunol. 2006 May;7(5):475-81.
• Kao C, Daniels MA, Jameson SC. Loss of CD8 and TCR binding to Class I MHC ligands following T cell activation. Int Immunol. 2005 Dec;17(12):1607-17.
• Prlic M, Gibbs J, Jameson SC. Characteristics of NK cell migration early after vaccinia infection. J Immunol. 2005 Aug 15;175(4):2152-7.
• Baldwin TA, Sandau MM, Jameson SC, Hogquist KA. The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med. 2005 Jul 4;202(1):111-21.
• Holman PO, Walsh ER, Jameson SC. Characterizing the impact of CD8 antibodies on class I MHC multimer binding. J Immunol. 2005 Apr 1;174(7):3986-91.

For a full listing of Dr. Jameson's publications, please Search PubMed.

Invited Lectures

• University of Rochester. Rochester, NY. September 18th 2008
• University of Toronto. Toronto, ON. March 17th 2008
• Massachusetts General Hospital. Boston, MA. January 31st 2008
• Harvard Medical School. Boston, MA. January 30th 2008
• Duke University. Durham, NC. January 16th 2007
• Yale University. New Haven, CT. February 1st 2007
• Washington University. Saint Louis, MO. March 26th 2007
• University Washington. Seattle, WA. April 9th 2007
• Robarts Research Institute. London, ON. May 17th 2007
• University of Massachusetts. Worcester, MA. September 19th 2007
• Centro de Investigación y de Estudios Avanzados. Mexico City, Mexico. November 27th 2007
• University of Maryland. Baltimore, MD. December 12th 2007
• University of Iowa. Iowa City, IA. March 20th 2006
• Johns Hopkins University. Baltimore, MD. December 5th 2006
• University of Texas Southwestern. Dallas, TX. January 26th 2005.
• University of Pennsylvania. Philadelphia, PA. February 22nd 2005.
• University of West Virginia. Morgantown, WV. April 27th 2005.
• Roswell Park Memorial Institute Cancer Center. Buffalo, NY. Nov 29th 2005.
• University of Chicago. Chicago, IL. February 23rd 2004
• Indiana University. Indianapolis, IN. March 11th 2004
• La Jolla Institute of Allergy and Immunology. La Jolla, CA. March 24th 2004
• Research Institute of Scripps Clinic. La Jolla, CA. March 25th 2004
• Kimmel Cancer Institute, Thomas Jefferson University. Philadelphia, PA. September 23rd 2004.
• Stanford University. Stanford, CA. January 28th 2003
• Yale University. New Haven, CT. February 27th 2003
• Johns Hopkins University. Baltimore, MD. March 18th 2003
• University of Massachusetts. Worcester, MA. April 24th 2003
• R&D Systems. Minneapolis, MN. May 1st 2003
• National Institutes of Health. Immunology Interests Group Seminar Series. Bethesda, MD. May 21st 2003.

Presentations

• Invited Speaker: Babraham Institute Diamond Jubilee Session on Cellular responses to the environment. Cambridge, England. June 26th – 27th 2008.
• Keynote Speaker: La Jolla Immunology Conference La Jolla, CA, October 21st-23rd 2008.
• Invited Speaker “Helping homeostatic memory CD8 T cells” at Keystone Symposium “Immunologic Memory” Santa Fe, New Mexico. March 3rd-8th 2007.
• Co-chair and Speaker: Minisymposium on Immunological Memory 13th International Congress of Immunology. Rio de Janeiro, Brazil. August 21st-25th 2007.
• Invited Speaker “Regulating Homeostatic Memory T Cell Function” XVII Mexican Congress of Immunology. Chihuahua, MEXICO. May 2nd - 5th 2006.
• Invited Speaker “Homeostasis of Naïve T cells” FASEB Summer Conference on Transplantation Immunology. June 3rd - 8th 2006.
• Invited Speaker “T cell homeostasis” 2nd International Symposium on primate research “From Cage to Clinic”: limitations and perspectives. Kunming, CHINA August 13th – 16th 2006.
• Invited Speaker “Characterizing memory T cells generated by homeostatic proliferation” at “Immunotherapy 2006: Targeting complexity” Center for Molecular Immunology, Havana, CUBA. November 15th-19th 2006.
• Symposium Chair “Homeostasis, memory and aging”. AAI Annual meeting. San Diego, CA. April 2nd – 6th 2005.
• Co-organizer and Speaker Bevan Birthday Symposium (a meeting in celebration of Mike Bevan’s 60th birthday). Seattle, WA. September 19th – 20th 2005.
• Invited Speaker “Homeostatic memory T cells” Immunological Memory: 15th Annual workshop of the Massachusetts General Hospital’s Center for the Study of Inflammatory Bowel Disease. Cambridge, MA. Nov 4th – 5th 2005.
• Invited Speaker Rolduc Workshop on T cell Biology. Rolduc Abbey, Kerkade, The Netherlands. May 1-4th 2004
• Invited Speaker Minisymposium on T cell development and function. Basel University, Basel, Switzerland. May 5th 2004.
• Workshop Co-Chair: 12th International Congress of Immunology. Session: “Lymphoid Homeostasis”. Montreal, Canada. July 18th – 23rd 2004.
• Invited Speaker Midwinter Conference of Immunologists: Asilomar, CA. January 25-28th, 2003.
• Invited Speaker 2003 Anderson Symposium “Initiation and regulation of the immune response”. University of Virginia. September 16th, 2003.