Kris Hogquist, Ph.D.

Associate Professor
612-625-1616
hogqu001@umn.edu

Educational Background

• College of St. Catherine, Minnesota (1983), B.A.
• Washington University, Missouri (1991), Ph.D.

Professional Background

• Research Assistant, University of Iowa, Laboratory of Richard Lynch, Iowa City, IA, 1983 – 1986
• Postdoctoral Fellowship, University of Washington, Laboratory of Michael Bevan, Seattle, WA, 1991 – 1995
• Assistant Professor, University of Minnesota, Center for Immunology, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 1995 – 2001
• Associate Professor, University of Minnesota, Center for Immunology, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 2001 - Present

Professional Memberships

• American Association of Immunologists (AAI)
• AAI Nominating Committee (Chair)
• Autumn Immunology Conference, Chair
• NIH study section (CMI-B)

Professional Honors

• Tozer Scholarship, 1979 – 1983
• Phi Beta Kappa Honor Society, 1982 – 1983
• National Science Foundation Fellowship, 1987
• JV Satterfield Arthritis Investigator Award, 1995
• McKnight Professorship, 1996
• Searle Scholar Award, 1997                                     

Publications

• Carlson, C.M., Endrizzi, B.T., Ding, X., Weinreich, M., Walsh, E.R., Wu, J., Wani, M.A., Lingrel, J.B., Hogquist, K.A., and S.C. Jameson.  Lung Kruppel-like factor (KLF2) regulates thymocyte and T cell migration. Manuscript submitted (2006).
• Mayerova, D, Wang, L., and K. A. Hogquist.  Conditioning of Langerhans cells induced by a primary CD8 T cell response to self-antigen in vivo.  Manuscript submitted (2005).
• McNeil, L.K., Starr, T.K., and K. A. Hogquist. A requirement for sustained ERK signaling during thymocyte positive selection in vivo.  Proc. Natl. Acad. Sci. 102:13574 (2005)
• Baldwin, T.A., Sandau, M.M, Jameson, S.C., and  K.A. Hogquist. The timing of TCR? expression critically influences T cell development and selection. J. Exp. Med. 202:111 (2005)
• Tze, L.T., Lam, K.P., Hogquist, K.A., Hippen K.L., Liu, J., Rodine P.R., Shinton, S.A., Vegoe, A.L., Hardy R.R., Rajewsky, K. and T.W. Behrens. Basal immunoglobulin signaling maintains allelic exclusion and developmental stage in immature B cells. PLOS 3:e82 (2005)
• Mick, V.E., Starr, T.K., McCaughtry, T.M., McNeil, L.K., and K.A. Hogquist. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo.  J. Immunol.  173:5434 (2004).
• Mayerova, D., Parke, E.A., Bursch, L.S., Odumade, O.A., and K.A. Hogquist. Langerhans cells activate naïve self-antigen specific CD8 T cells in the steady state.  Immunity 21:391 (2004)
• D. Mayerova and K.A. Hogquist Central tolerance to self-antigen expressed by cortical epithelial cells. J.  Immunol. 172:851 (2004).
• Holman, P.O., Walsh, E.R., and K.A. Hogquist.  The central tolerance response to male antigen in normal mice is clonal deletion and not receptor editing. J. Immunol. 171:4048 (2003).
• Starr, T.K., Daniels, M.A., Lucido, M.M., Jameson S.C., and K.A. Hogquist. Thymocyte sensitivity and SMAC formation are developmentally regulated: a role for sialylation. J. Immunol. 171:4512 (2003)
• Marshall, D., Bagley, J., Le, P., Hogquist K., Cyr, S., vo Schild, E., Pykett, M., and M. Rosenzweig.  T cell generation including poisitive and negative selection ex vivi in a three-dimensional matrix.   Journal of Hematotherapy 12:565 (2003)
• Santori F.R., Kieper W.C., Brown S.M., Lu, Y., Neubert, T.A., Johnson, K.L., Naylor, S., Vukmanovic, S., Hogquist, K.A. and S.C. Jameson  Rare, structurally homologous self-peptides promote thymocyte positive selection.  Immunity 17:131. (2002)
• McGargill, M.A., Mayerova, D., Stefanski, H.E., Koehn, B., Parke, E.A., Jameson S.C., Panoskaltsis-Mortari, A., and K.A. Hogquist.   A spontaneous CD8 T cell dependent autoimmune disease to an antigen expressed under the K14 promoter. J. Immunol. 169(4):2141-7 (2002)
• Puls, K.L., Hogquist, K.A., Reilly, N. and M.D. Wright.  CD53, a thymocyte selection marker whose induction requires a lower affinity T cell receptor/MHC interaction than CD69, but is upregulated with slower kinetics. International Immunology;14 249-258 (2002).
• Daniels, M.A., Devine, L., Miller, J.D., Moser, J.M., Lukacher, A., Altoman, J., Kavathas, P., Hogquist, K.A., and S.C. Jameson CD8 binding to MHC Class I molecules is influenced by T cell maturation and glycosylation.Immunity 15(6):1051-61 (2001)
• Stefanski, H.E., Mayerova D., Jameson, S.C.  K.A. Hogquist.  A low affinity ligand restores positive selection of CD8+ Tcells in vivo.  J. Immunol. 166:6602 (2001)
• McGargill, M.M., Derbinski, J.M., and K.A. Hogquist.  Receptor editing in developing T cells.  Nature Immunology,  1:336 (2000)
• Stefanski, H.E., Jameson, S.C., and K.A. Hogquist.  Positive selection is limited by available peptide-dependent MHC conformations.  J. Immunol. 164:3519-3526 (2000)
• Alam, SM., Lin, C.M., Davies,  M., Jameson, S.C., Hogquist, K.A., Gascoigne, N.R.J., and P.J. Travers.  T cell receptor dimerization on binding agonist but not antagonist ligands.  Immunity  10:227  (1999)
• Daniels, M.A., Schober, S.L., Hogquist, K.A., and S.C. Jameson.  Cutting Edge: A test of the dominant negative signal model for TCR antagonism.  J. Immunol.  162:3761 (1999). 
• McGargill, M.M. and K.A. Hogquist.  Antigen-induced co-receptor downregulation on thymocytes is not a result of apoptosis.  J.  Immunol.  162:1237-1245  (1999)
• Davey, G.M., Schober, S.L., Endrizzi, B.T., Dutcher, A.K., S. C. Jameson, and K.A. Hogquist.  Pre-selection thymocytes are more sensitive to TCR stimulation than mature T cells.  J. Exp. Med. 10:1867 (1998).
• Hogquist, K.A. and J. L. Bonnevier.  Development of peptide selected CD8 T cells in fetal thymic organ culture occurs via the conventional pathway.  J. Immunol.  161:3896-3901 (1998)
• Goldrath, A.W., Hogquist, K.A., and M.J. Bevan.  CD8 lineage commitment in the absence of CD8.   Immunity  6:633-642 (1997).
• Hogquist, K.A., Tomlinson, A.J., Kieper, W.C., McGargill, M.A., Naylor, S., and S. C. Jameson.  Identification of a naturally occurring ligand for positive selection. Immunity  6(4):389-399 (1997).
• Alberola-Ila, J., Hogquist, K.A., Swan, K.A., Bevan, M.J. and Perlmutter, R.M. Positive and Negative Selection Invoke Distinct Signaling Pathways.  J. Exp. Med.   184: 9-18 (1996).
• Hogquist, KA, Jameson, SC, and MJ Bevan.  Strong agonist ligands for the T cell receptor do not induce positive selection of functional CD8+ T cells.  Immunity,  3:79-86 (1995).
• Jameson, SC, Hogquist, KA, and MJ Bevan.  Specificity and flexibility in thymic selection.  Nature  369:750-752 (1994).
• Gavin, MA, Dere, B, Grandea, AGIII, Hogquist, KA, and MJ Bevan.  MHC classI allele-specific peptide libraries: Identification of peptides that mimic an H-Y T cell epitope.  Eur. J. Immunol. 24:2124-33 (1994).
• Hogquist, KA, Jameson SC, Heath, WR, Howard, JL,Bevan, MJ, and FR Carbone.  T cell receptor antagonist peptides induce positive selection.  Cell  76:17-27.  (1994)
• Vukmanovic, S, Stella G, King, PD, Dyall, R, Hogquist, KA, Harty, JT, Nikolic-Zugic, J, and MJ Bevan.  A positively selecting thymic epithelial cell line lacks costimulatory activity.  J. Immunol. 152: 3814. (1994)
• Hogquist, KA, AG Grandea III, and MJ Bevan.  Peptide variants reveal how antibodies recognize major histocompatibility complex class I.  Eur. J. Immunol. 23:3028. (1993)
• Hogquist, KA, MA Gavin, and MJ Bevan.  Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.  J. Exp. Med. 177:1469-73. (1993)
• Howard, AD, MJ Kostura, N Thornbury, GJ Ding, G Limjuco, J. Weidner, JP Salley,
• KA Hogquist, DD Chaplin, RA Mumford et al.  mIL-1 converitng enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDA IL-1 alpha.  J. Immunol.  47:2964-9. (1991)
• Hogquist, KA, MA Nett, ER Unanue, and DD Chaplin.  Interleukin-1 is processed and released during apoptosis.  Proc. Natl. Acad. Sci.(USA) 88:8455-9. (1991)
• Hogquist, KA, ER Unanue, and DD Chaplin.  Interleukin-1 release from mononuclear phagocytes. J. Immunol. 147:2181-6. (1991)
• Hogquist, KA, MA Nett, KCF Sheehan, KD Pendleton, RD Schreiber, and DD Chaplin.  Generation of monclonal antibodies to murine IL-1 beta and demonstrtion of IL-1 in vivo.  J. Immunol.  146:1534-1540.  (1991)
• Rosenwasser, TA, KA Hogquist, SF Nothwehr, S Bradford-Goldberg, PO Olins, DD Chaplin and JI Gordon.  Compartmentalization of mammalian proteins produced in Escherichia Coli.  J. Biol. Chem.  265:13066.  (1990)
• Hogquist K.A., Baldwin T.A. and S.C. Jameson.  Central Tolerance: Learning Self Control in the Thymus.  Nature Reviews Immunology In Press (2005).
• Baldwin, T.A., Starr, T.K., and K. A. Hogquist. Murine Models of Negative Selection. The Mouse in Biomedical Research In Press (2005)
• Hogquist, KA, TA Baldwin, and SC Jameson.  The fourth way?  Harnessing aggressive tendencies in the thymus.  J. Immunol.  173:6515 (2004).
• Hogquist, KA, Starr, TK, and SC Jameson. Dispatch: When T cells lose their sense of self.  Current Biology. 13(6):239-41. (2003).
• Nemazee, D and KA Hogquist. Antigen receptor selection by editing or downregulation of V(D)J recombination.  Current Opinion in Immunology. 15(2):182-9 (2003).
• Starr TK,  Jameson, SC and KA Hogquist.  Positive and Negative Selection of T cells.  Annual Reviews in Immunology  21:139-76 (2003).
• Hogquist, KA.  Tissue specific antigens come up for AIRE.  BioMedNet, December 18 (2002)
• Hogquist, KA. Surviving without a TCR.  Trends Immunol. Sep;22(9):476-7 (2001)
• Hogquist, KA.  Getting TCR transgenics to work on time.  Trends Immunol. May;22(5):240. (2001)
• Hogquist, KA.  RasGRP: the missing link for Ras activation in thymocytes.  Trends Immunol. Feb:22(2):69. (2001)
• KA Hogquist.  Signal strength in thymic selection and lineage commitment.  Current Opinion in Immunology  13:225-231 (2001).
• McGargill, MA and KA Hogquist.  T cell receptor editing.  Immunology Letters 75:27-31 (2000).
• KA Hogquist.  Assays of thymic selection: fetal thymus organ culture and an in vitro DP dulling assay.  Methods in Molecular Biology   156:219 (2000).
• Hogquist, KA, and MJ Bevan.  The nature of the peptide/MHC ligand involoved in positive seletion.  Sem. in Immunol.  88:63 (1996).
• Jameson, SC, Hogquist, KA, and MJ Bevan.  Positive selection of thymocytes  Ann. Rev. Immunol.  13,93-126 (1995)
• MJ Bevan, KA Hogquist, and SC Jameson.  Selecting the T cell receptor repertoire.   Science  264:296-297 (1994)
• Hogquist, KA, Jameson SC, and MJ Bevan.  The ligand for positive selection of T lymphocytes in the thymus.  Current Opinion in Immunology   6:273-278. (1994)
• Vukmanovic, S, MJ Bevan, and KA Hogquist.  The specificity of positive selection: MHC and peptides.  Immunological Reviews 135:1. (1993)
• Jameson, SC and KA Hogquist.  “Options for TCR interactions: TCR agonist, antagonist, and partial agonists”, MHC Molecules: Expression, Assembly, and Function.  RG Urban and RM Chicz, eds. RG Landes Company, Austin, Texas (1996)
• Chaplin, DD and KA Hogquist.  “Interactions between TNF and Interleukin-1”,  Biology of the TNFs. B Beutler ed.  Raven Press, New York.  (1991)
• Fuhlbrigge, RC, KA Hogquist, ER Unanue, and DD Chaplin.  “Molecular Biology and Genetics of Interluekin-1”,  The Year in Immunology. 5th ed.  J.M. Cruse and RE Lewis, eds. S Karger, Basel p21-37.  (1989)