Stephen Hecht, Ph.D.

Professor
612-624-7604
hecht002@umn.edu

Educational Background

• Duke University, North Carolina (1964), B.S. (Chemistry)
• Massachusetts Institute of Technology, Massachusetts (1968), Ph.D. (Organic Chemistry)

Professional Background

• Wallin Professor of Cancer Prevention, University of Minnesota, Cancer Center, Minneapolis, MN, 1996 - present
• Director of Research, American Health Foundation, Naylor Dana Institute for Disease Prevention, Valhalla, NY, 1987 - 1996
• National Research Council Fellow, Agricultural Research Service, United States Department of Agriculture, Philadelphia, PA, 1971 - 1973
• Assistant Professor of Chemistry, Haverford College, Haverford, PA, 1969 - 1971
• Chief, Division of Chemical Carcinogenesis, American Health Foundation, Naylor Dana Institute for Disease Prevention, Valhalla, NY, 1980 - 1996
• Head, Section of Organic Chemistry, Division of Environmental Carcinogenesis, American Health Foundation, Naylor Dana Institute for Disease Prevention, Valhalla, NY, 1973 - 1980

Professional Honors

• Phi Beta Kappa
• National Research Council Research Fellow, 1971 - 1973
• Research Career Development Award, National Cancer Institute, 1975 - 1980
• Outstanding Investigator Grant, National Cancer Institute, 1987 - 2001
• Cancer Research Covers, March 1, 1988; February 15, 1993
• Endowed Chair in Carcinogenesis and Chemoprevention, American Health Foundation, 1992 - 1996
• Wallin Chair in Cancer Prevention, University of Minnesota, 1996 - present
• American Cancer Society Research Professor, 1999 - present
• Alton Ochsner Award Relating Smoking and Health, 2001

Community and University Service

• Surgeon General’s Report, Passive Smoking and Health, Contributor, 2002
• Lung Cancer Progress Review Group, National Cancer Institute, 2001
• American Cancer Society, Chair, 2001, Peer Review Committee on Carcinogenesis, Nutrition, and the Environment, 1998 - 2001
• National Center for Toxicological Research, FDA, Science Advisory Board, 1998
• National Toxicology Program, Board of Scientific Counselors, 1997 - 2001
• Division of Chemical Toxicology, American Chemical Society, Chair, 1999-2000; Chair-elect, 1997-1998; Program Chair, 1996
• National Cancer Institute, Board of Scientific Counselors, Division of Cancer Etiology, 1989 - 1995
• National Institutes of Health, Chemical Pathology Study Section; Ad hoc, 1998, 1981 - 1985
• American Institute for Cancer Research, Grants Review Panel, 1984 - 1987
• Health Effects Institute, Health Research Committee, 1992 - 1996
• Oregon State University, External Advisory Committee, Environmental Health Sciences Center, 1996 - 2001
• Massachusetts Institute of Technology, Corporation Visiting Comm., Div of Bioengineering and Environmental Health, 2000
• Vanderbilt University, Advisory Group, Center in Molecular Toxicology; Chairman, 1995-1997, 1991 - 1997
• Editorial Boards:, Cancer Research; Cancer Epidemiology, Biomarkers & Prevention; Cancer Letters; Carcinogenesis; Lung Cancer Program Comm., Amer. Assoc. for Cancer Research, 1983, 1990, 1993, 1997, 2000; Session chair, 1984, 1986, 1988, 1991, 2000
• National Cancer Institute, Upper Aerodigestive Cancer Working Group, 1986 - 1989
• Carcinogenesis Technical Support Comm., Surgeon General's Report: Health Consequences of Using Smokeless Tobacco, 1986
• Organizing Committee, NIH Consensus Development Conference on the Health Implications of Smokeless Tobacco, 1986
• Chemical Carcinogenesis, Principal Lecturer, American Chemical Society Short Course, 1979 - 1983
• Consultant, WHO, IARC, Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 1984
• Thesis Committees: Rutgers Univ, Massachusetts Institute of Technology, Columbia Univ, Univ of Minnesota

Publications

• Hecht, S.S., Ye, M., Carmella, S.G., Fredrickson, A., Adgate, J.L., Greaves, I.A., Church, T.R., and Sexton, K. Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children. Cancer Epidemiol. Biomarkers & Prev., in press, 2001.
• Wang, M., McIntee, E.J., Cheng, G., Shi, Y., Villalta, P.W., and Hecht, S.S. Reactions of 2,6-dimethyl-1,3-dioxane-4-ol (aldoxane) with deoxyguanosine and DNA. Chem. Res. Toxicol., in press, 2001.
• Baum, M., Amin, S., Guengerich, F.P., Hecht, S.S., Köhl, W., and Eisenbrand, G. Metabolic activation of benzo[c]phenanthrene by cytochrome P450 enzymes in human liver and lung. Chem. Res. Toxicol., 14: 686-693, 2001.
• Upadhyaya, P., McIntee, E.J., and Hecht, S.S. Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines. Chem. Res. Toxicol., 14: 555-561, 2001.
• Wang, M., McIntee, E.J., Cheng, G., Shi, Y., Villalta, P.W., and Hecht, S.S. A Schiff base is a major DNA adduct of crotonaldehyde. Chem. Res. Toxicol., 14: 423-430, 2001.
• Hecht, S.S., Kenney, P.M.J., Wang, M., and Upadhyaya, P. Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Lett., 167: 1-6, 2001.
• Wang, M., McIntee, E.J., Cheng, G., Shi, Y., Villalta, P.W., and Hecht, S.S. Identification of DNA adducts of acetaldehyde. Chem. Res. Toxicol., 13: 1149-1157, 2001.
• Anderson, K.E., Carmella, S.G., Ye, M., Bliss, R.L., Le, C., Murphy, L., and Hecht, S.S. Metabolites of a tobacco-specific lung carcinogen in the urine of nonsmoking women exposed to environmental tobacco smoke in their homes. J. Natl Cancer Inst., 93: 378-381, 2001.
• Liebes, L., Conaway, C.C., Hochster, H., Mendoza, S., Hecht, S.S., Crowell, J., and Chung, F-L. HPLC based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate. Anal. Biochem., in press, 2001.
• Murphy, S.E., Johnson, L.M., Losey, L.M., Carmella, S.G., and Hecht, S.S. Effects of watercress consumption on coumarin metabolism in humans. Drug Metab. Disp., 29: 786-788, 2001.
• Hecht, S.S. Carcinogen biomarkers for lung or oral cancer chemoprevention trials. In: Biomarkers in Cancer Chemoprevention (A.B. Miller, H. Bartsch, P. Boffetta, L. Dragsted, and H. Vainio, eds.) IARC Scientific Publications No. 154, Lyon, France, pp. 245-255, 2001.
• Hecht, S.S., Hochalter, J.B., Villalta, P.W., and Murphy, S.E. 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor. Proc. Natl. Acad. Sci. USA, 97: 12493-12497, 2000.
• Wang, M., McIntee, E.J., Cheng, G., Shi, Y., Villalta, P.W., and Hecht, S.S. Identification of paraldol-deoxyguanosine adducts in DNA reacted with crotonaldehyde. Chem. Res. Toxicol. 13:1065-1074, 2000.
• Sticha, K.R.K., Staretz, M.E., Wang, M., Liang, H., Kenney, P.M.J., and Hecht, S.S. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse. Carcinogenesis, 21: 1711-1719, 2000.
• Simpson, C.D., Wu, M.-T., Christiani, D.C., Santella, R.M., Carmella, S.G., and Hecht, S.S. Determination of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography-negative ion chemical ionization-mass spectrometry. Chem. Res. Toxicol., 13: 271-280, 2000.
• Upadhyaya, P., Carmella, S.G., Guengerich, F.P., and Hecht, S.S. Formation and metabolism of 4Ó(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat, and human tissues. Carcinogenesis, 21: 1233-1238, 2000.
• Carmella, S.G., McIntee, E.J., Chen, M., and Hecht, S.S. Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobacco. Carcinogenesis, 21: 839-843, 2000.
• McIntee, E.J. and Hecht, S.S. Metabolism of N'-nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats. Chem. Res. Toxicol., 13: 192-199, 2000.
• Milunsky, A., Carmella, S.G., Ye, M., and Hecht, S.S. A tobacco-specific carcinogen in the fetus. Prenat. Diagn., 20: 307-310, 2000.
• Hecht, S.S., Kenney, P.M.J., Wang, W., Trushin, N., and Upadhyaya, P. Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Lett., 150: 49-56, 2000.
• Hecht, S.S., Trushin, N., Chhabra, S.K., Anderson, L.M., and Nerurkar, P.V. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cultured monkey lung explants. Drug Metab. Disp., 28: 5-9, 2000.
• Hecht, S.S. Inhibition of carcinogenesis by isothiocyanates. Drug Metabol. Rev., 32: 395-411, 2000.
• Hecht, S.S. Chemoprevention by phytochemical modifiers of carcinogen metabolism. In: Pytochemicals as Bioactive Agents, (W.R. Bidlack, S.T. Omaye, M.S. Meskin, and D.K.W. Topham eds.), Lancaster, PA: Technomic Publishing Co., pp. 43-74, 2000.
• Hecht, S.S. Anticarcinogenesis by isothiocyanates, indole-3-carbinol, and Allium thiols. In: Carcinogenic and Anticarcinogenic Factors in Food (G. Eisenbrand, A.D. Dayan, P. S. Elias, W. Grunow and J. Schlatter, eds.) Wiley-VCH, pp. 306-333, 2000.
• Wang, M., McIntee, E.J., Cheng, G., Shi, Y., Villalta, P.W., and Hecht, S.S. Reactions of 2,6-dimethyl-1,3-dioxane-4-ol (aldoxane) with deoxyguanosine and DNA. Chem. Res. Toxicol., 14:1025-1032, 2001.
• Wang, M., McIntee, E.J., Shi, Y., Cheng, G., Upadhyaya, P., Villalta, P.W., and Hecht, S.S. Reactions of a-acetoxy-N-nitrosopyrrolidine with deoxyguanosine and DNA. Chem. Res. Toxicol., 14: 1435-1445, 2001.
• Wong, H.L., Murphy, S.E., Wang, M., and Hecht, S.S. Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine in rat liver and esophageal microsomes. Carcinogenesis, submitted, 2002
• Hecht, S.S., McIntee, E.J., and Wang, M. New DNA adducts of crotonaldehyde and acetaldehyde. Toxicology, 166: 31-36, 2001.
• Wu, M., Simpson, C.D., Christiani, D.C., Chang, L.W., and Hecht, S.S. Relationship of exposure to coke-oven emissions and urinary metabolites of benzo[a]pyrene and pyrene in coke-oven workers. Cancer Epidemiol. Biomarkers & Prev., 11: 311-314, 2002.
• Hecht, S.S. Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. Carcinogenesis, in press, 2002
• Hecht, S.S. Tobacco smoke carcinogens and breast cancer. Env. Mol. Mutagen., 39: 119-126, 2002
• Hecht, S.S. Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. The Lancet Oncology, 2002, submitted
• Cheng,G., Shi,Y., Sturla,S., Jalas,J., McIntee,E.J., Villalta,P.W., Wang,M., and Hecht,S.S. (2003) Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links. Chem.Res.Toxicol., 16, 145-152.
• Carmella,S.G., Chen,M., Villalta,P.W., Gurney,J.G., Hatsukami,D.K., and Hecht,S.S. (2002) Ethylation and methylation of hemoglobin in smokers and non-smokers. Carcinogenesis, 23 , 1903-1910.
• Hecht,S.S. (2002) Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. The Lancet Oncology, 3, 461-469.
• Wong, H.L., Murphy, S.E., and Hecht, S.S. Preferential metabolic activation of N-nitrosopiperidine compared to its structural homolog N-nitrosopyrrolidine by rat nasal microsomes. Chem. Res. Toxicol., 16: 1298-1305, 2003
• Hecht, S.S. Carcinogen-derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke. Tob Control, 13 Suppl 1: 48-56, 2004
• Hecht, S.S. Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. The Lancet Oncology, 3: 461-469, 2002