William Gleason, Ph.D.

Associate Professor
612-626-2455
bgleason@umn.edu

http://ccgb.umn.edu/~bgleason/cv.html

Educational Background

• Northwestern University, Illinois (1967), B.A. (Chemistry)
• University of Iowa, Iowa (1970), M.S. (Biochemistry)
• University of Minnesota, Minnesota (1973), Ph.D (Organic Chemistry)

Professional Background

• Postdoctoral Fellow , University of Minnesota, Department of Chemistry, EDIT, 1973 - 1974
• Assistant Professor (non-tenure track), Carleton College, Northfield, MN, EDIT, 1974 - 1977
• Assistant Professor (temporary position), College of St. Catherine, St. Paul, MN, EDIT, 1977 - 1980
• Senior Research Chemist, 3M Company, St. Paul, MN, EDIT, 1980 - 1989
• Research Associate, Department of Medicinal Chemistry, Minnesota Supercomputer Institute, and Department of Biochemistry, University of Minnesota, EDIT, 1989 - 1992
• Assistant Professor (tenure track), Biomedical Engineering Center , University of Minnesota , Department of Laboratory Medicine and Pathology, EDIT, 1992 - 1998
• Member of the Graduate Faculty: Biomedical Engineering, University of Minnesota, EDIT, 1993
• Associate Professor (with tenure), Laboratory Medicine & Pathology, University of Minnesota, Department of Laboratory Medicine and Pathology, 1998 - present
• Member of the Graduate Faculty, Chemistry, University of Minnesota, 1999 - present
• Member of the Graduate Faculty: Biomedical Engineering, Medicinal Chemistry, Molecular Pathobiology, University of Minnesota, 1992 - present

Professional Memberships

• American Chemical Society, 1970 - present
• American Crystallographic Association, 1973 - present
• American Association for the Advancement of Science, 1990 - present
• Society for Glycobiology, 1992 - present
• American Society for Virology, 1992 - present
• Society for Biomaterials, 1993 - present
• Phi Lambda Upsilon, elected, 1970
• Sigma Xi, 1974 - present

Professional Honors

• Lee I. Smith Award: Outstanding Organic Chemistry Research Graduate Student, University of Minnesota, 1973
• Teacher of the Year, College Association Governing Board, College of St. Catherine, St. Paul, MN, 1980
• National Service Award, American Crystallographic Association, 1991
• Associate Fellow, Minnesota Supercomputer Institute, 1995 - 1998
• Fellow, Minnesota Supercomputer Institute, 1998 - present

Publications

• Zhou, B., Nelson, T.R., Kashtan, C., Gleason, W.B., Michael, A.F., Vlassi, M., and Charonis, A. S., Identification of two alternatively spliced forms of human tubolointerstitial nephritis antigen (TIN-Ag). Journal of the American Society of Nephrology, 11(4), 658-68 (2000).
• Ojala, W. H., Ojala, C. R., and Gleason, W. B., Crystal and molecular structures of derivatives formed by reaction between toluenesulfonhydrazide and D-glucose, D-galactose, and L-arabinose, Journal of Chemical Crystallography., 29, 19-26 (1999).
• Evans, M. C., Pradhan, A., Venkatraman, S., Ojala, W. H., Gleason, W. B., Mishra, R. K., and Johnson, R. L., Synthesis and dopamine receptor modulating activity of novel peptidomimetics of L-prolyl-L-leucyl-glycinamide featuring alpha,alpha-disubstituted amino acids, Journal of Medicinal Chemistry., 42, 1441-1447 (1999).
• Baures, P. W., Pradhan, A., Ojala, W. H., Gleason, W. B., Mishra, R. K., and Johnson, R. L., Synthesis and dopamine receptor modulating activity of unsubstituted and substituted triproline analogues of L-prolyl-L-leucyl-glycinamide (PLG), Bioorganic & Medicinal Chemistry Letters., 9, 2349-2352 (1999).
• Ojala, C. R., Ojala, W. H., Gleason, W. B., and Britton, D., The crystal structures of p-ido-N-(p-cyanobenzylidene)aniline and p-cyano-N-(p-iodobenzylidene)aniline, Journal of Chemical Crystallography., 29, 27-32 (1999).
• Khalil, E. M., Ojala, W. H., Pradhan, A., Nair, V. D., Gleason, W. B., Mishra, R. K., and Johnson, R. L., Design, synthesis, and dopamine receptor modulating activity of spiro bicyclic peptidomimetics of L-prolyl-L-leucyl-glycinamide, Journal of Medicinal Chemistry, 42, 628-637 (1999).
• Khalil, E. M., Pradhan, A., Ojala, W. H., Gleason, W. B., Mishra, R. K., and Johnson, R. L., Synthesis and dopamine receptor modulating activity of substituted bicyclic thiazolidine lactam peptidomimetics of L-prolyl-L-leucyl-glycinamide, Journal of Medicinal Chemistry., 42, 2977-2987 (1999).
• Ojala, C. R., Ojala, W. H., Pennamon, S. Y., and Gleason, W. B., Conformational Polymorphs of Acetone Tosylhydrazone, Acta Crystallographica - Section C - Crystal Structure Communications, 54, 57-60 (1998).
• Ojala, W. H., and Gleason, W. B., Cyclopentanone Tosylhydrazone and Cyclohexanone Tosylhydrazone, Acta Crystallographica - Section C - Crystal Structure Communications, 54, 63-66 (1998).
• Ojala, C. R., Ojala, W. H., and Gleason, W. B., By-Products From the Preparation of Acetone Tosylhydrazone - 4,5-Dihydro-3,5,5-Trimethyl-1-[(4-Methylphenyl)Sulfonyl]-1h-Pyrazole and 1,2-Bis(P-Toluenesulfono)-Hydrazide, Acta Crystallographica - Section C - Crystal Structure Communications, 54, 60-63 (1998).
• Akkani, A., Paterlini, G., Gleason, W. B., Ojala, W. H., and Abul-Hajj, Y. J., 6 beta-Propynyl-substituted steroids: mechanism-based enzyme-activated irreversible inhibitors of aromatase, Journal of Medicinal Chemistry, 40, 3263-70 (1997).
• Baures, P. W., Ojala, W. H., Gleason, W. B., and Johnson, R. L., Conformational Analysis of Homochiral and Heterochiral Diprolines As Beta-Turn-Forming Peptidomimetics - Unsubstituted and Substituted Models, International Journal of Peptide & Protein Research, 50, 1-13 (1997).
• Ojala, W. H., Iyer, R. A., Hanna, P. E., and Gleason, W. B., Heterocyclic N-Acetoxyarylamines, Models For the Putative Ultimate Carcinogens of Aromatic Amines - 2-Acetoxyamino-5-Phenylpyridine and 2-Acetoxyaminopyridine, Acta Crystallographica - Section C - Crystal Structure Communications, 53, 634-637 (1997).
• Baures, P. W., Ojala, W. H., Costain, W. J., Ott, M. C., Pradhan, A., Gleason, W. B., Mishra, R. K., and Johnson, R. L., Design, Synthesis, and Dopamine Receptor Modulating Activity of Diketopiperazine Peptidomimetics of L-Prolyl-L-Leucylglycinamide, Journal of Medicinal Chemistry, 40, 3594-3600 (1997).
• Akkani, A., Paterlini, G., Gleason, W. B., Ojala, W. H., and Abulhajj, Y. J., 6-Beta-Propynyl-Substituted Steroids - Mechanism-Based Enzyme-Activated Irreversible Inhibitors of Aromatase, Journal of Medicinal Chemistry, 40, 3263-3270 (1997).
• Ojala, W. H., Gleason, W. B., Connelly, M. P. E., Wallis, R. R., and Kremer, J. J., Polymerizable Methacrylate Carbohydrate Derivatives - 1,2/3,4-Di-O-Isopropylidene-6-O-Methacryloyl-Alpha-D-Galactopyranose and 1,2/5,6-Di-O-Isopropylidene-3-O-Methacryloly-Alpha-D-Glucofuranose, Acta Crystallographica - Section C - Crystal Structure Communications, 52, 155-158 (1996).
• Ojala, W. H., Sudbeck, E. A., Lu, L. K., Richardson, T. I., Lovrien, R. E., and Gleason, W. B., Complexes of Lysine, Histidine, and Arginine With Sulfonated Azo Dyes - Model Systems For Understanding the Biomolecular Recognition of Glycosaminoglycans By Proteins, Journal of the American Chemical Society, 118, 2131-2142 (1996).
• Ojala, W. H., and Gleason, W. B., Mannose Phenylhydrazone, an Acyclic Monosaccharide Derivative, Acta Crystallographica - Section C - Crystal Structure Communications, 52, 3188-3190 (1996).
• Abul-Hajj, Y. J., Tabakovic, K., Gleason, W. B., and Ojala, W. H., Reactions of 3,4-estrone quinone with mimics of amino acid side chains, Chemical Research in Toxicology, 9, 434-8 (1996).
• Ojala, W. H., Khankari, R. K., Grant, D. J. W., and Gleason, W. B., Crystal Structures and Physical Chemical Properties of Nedocromil Zinc Heptahydrate and Nedocromil Magnesium Pentahydrate, Journal of Chemical Crystallography, 26, 167-178 (1996).
• Bolognesi, M., Ojala, W. H., Gleason, W. B., Griffin, J. F., Farouzgrant, F., Larson, D. L., Takemori, A. E., and Portoghese, P. S., Opioid Antagonist Activity of Naltrexone-Derived Bivalent Ligands - Importance of a Properly Oriented Molecular Scaffold to Guide Address Recognition At Kappa Opioid Receptors, Journal of Medicinal Chemistry, 39, 1816-1822 (1996).
• Zhu, H. J., Khankari, R. K., Padden, B. E., Munson, E. J., Gleason, W. B., and Grant, D. J. W., Physicochemical Characterization of Nedocromil Bivalent Metal Salt Hydrates .1. Nedocromil Magnesium, Journal of Pharmaceutical Sciences, 85, 1026-1034 (1996).
• Tabakovic, K., Gleason, W. B., Ojala, W. H., and Abulhajj, Y. J., Oxidative Transformation of 2-Hydroxyestrone - Stability and Reactivity of 2,3-Estrone Quinone and Its Relationship to Estrogen Carcinogenicity, Chemical Research in Toxicology, 9, 860-865 (1996).
• Gleason, W. B., Calculated Powder Patterns of (R,S)-Propanolol Hydrochloride - Comment, International Journal of Pharmaceutics, 127, 109-112 (1996).
• Ojala, W. H., Ojala, C. R., and Gleason, W. B., The X-Ray Crystal Structure of the Sulfonated Azo Dye Congo Red, a Non-Peptidic Inhibitor of Hiv-1 Protease Which Also Binds to Reverse Transcriptase and Amyloid Proteins, Antiviral Chemistry & Chemotherapy, 6, 25-33 (1995).
• Ojala, W. H., Albers, K. E., Gleason, W. B., and Choo, C. G., Carbohydrates With Relevance to the Structure of Glycosaminoglycans - the Crystal Structures of 2-Deoxy-2-(Sulfoamino)-Alpha-D-Glucopyranose Sodium Salt Dihydrate, 2-Amino-2-Deoxy-Alpha,Beta-D-Glucopyranose 3-(Hydrogen Sulfate) Monohydrate, and 2-Amino-2-Deoxy-Alpha-D-Glucopyranose 6-(Hydrogen Sulfate) Monohydrate, Carbohydrate Research, 275, 49-65 (1995).
• Khankari, R. K., Ojala, W. H., Gleason, W. B., and Grant, D. J. W., Crystal Structure of Nedocromil Sodium Heptahemihydrate and Its Comparison With That of Nedocromil Sodium Trihydrate, Journal of Chemical Crystallography, 25, 863-870 (1995).
• Sudbeck, E. A., Gleason, W. B., and Etter, M. C., Crystal Structures and Hydrogen Bond Analysis of Three Arenesulfonate Salts of L-Alanine, Glycine, and L-Serine, Journal of Chemical Crystallography, 25, 555-567 (1995).
• Ghosh, S., Ojala, W. H., Gleason, W. B., and Grant, D. J. W., Relationships Between Crystal Structures, Thermal Properties, and Solvate Stability of Dialkylhydroxypyridones and Their Formic Acid Solvates, Journal of Pharmaceutical Sciences, 84, 1392-1399 (1995).
• Abulhajj, Y. J., Tabakovic, K., Ojala, W. H., and Gleason, W. B., Crystalline Diethylstilbestrol (Des) Quinone - Synthesis, X-Ray Analysis, and Stability, Journal of the American Chemical Society, 117, 5600-5601 (1995).
• Baures, P. W., Ojala, W. H., Gleason, W. B., Mishra, R. K., and Johnson, R. L., Design, synthesis, X-ray analysis, and dopamine receptor-modulating activity of mimics of the "C5" hydrogen-bonded conformation in the peptidomimetic 2-oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1- pyrrolidineacetamide, Journal of Medicinal Chemistry, 37, 3677-83 (1994).
• Chang, A. C., Takemori, A. E., Ojala, W. H., Gleason, W. B., and Portoghese, P. S., Kappa Opioid Receptor Selective Affinity Labels - Electrophilic Benzeneacetamides As Kappa-Selective Opioid Antagonists, Journal of Medicinal Chemistry, 37, 4490-4498 (1994).
• Byrn, S. R., Pfeiffer, R. R., Stephenson, G., Grant, D. J. W., and Gleason, W. B., Solid-State Pharmaceutical Chemistry [Review], Chemistry of Materials, 6, 1148-1158 (1994).
• Ojala, W. H., Gleason, W. B., Richardson, T. I., and Lovrien, R. E., Interactions Between Sulfonated Azo Dyes and Biomolecules - Orange-G Adenine and Orange-G Cytosine Salts, Acta Crystallographica - Section C - Crystal Structure Communications, 50, 1615-1620 (1994).
• Ojala, W. H., Lu, L. K., Albers, K. E., Gleason, W. B., Richardson, T. I., Lovrien, R. E., and Sudbeck, E. A., Intermolecular Interactions of Sulfonated Azo Dyes - Crystal Structures of the Diammonium, Dilithium, Magnesium and Calcium Salts of 7-Hydroxy-8-(Phenylazo)-1,3-Naphthalenedisulfonic Acid (Orange G), Acta Crystallographica - Section B, Structural Science, 50, 684-694 (1994).
• Sudbeck, E. A., Etter, M. C., and Gleason, W. B., Growth of High-Quality Crystals Containing Peptides - Arenesulfonate Salts of L-Alanyl-L-Alanine, Glycylglycine, and L-Leucyl-L-Alanine, Chemistry of Materials, 6, 1192-1199 (1994).
• Gleason, W. B., Fu, Z. J., Birktoft, J., and Banaszak, L., Refined Crystal Structure of Mitochondrial Malate Dehydrogenase From Porcine Heart and the Consensus Structure For Dicarboxylic Acid Oxidoreductases, Biochemistry, 33, 2078-2088 (1994).
• Perentesis, J. P., Phan, L. D., Gleason, W. B., LaPorte, D. C., Livingston, D. M., and Bodley, J. W., Saccharomyces cerevisiae elongation factor 2. Genetic cloning, characterization of expression, and G-domain modeling, Journal of Biological Chemistry, 267, 1190-7 (1992).