John H. Eckfeldt, M.D., Ph.D.

Professor
612-626-3176
eckfe001@umn.edu

Dr. Eckfeldt is Professor of Laboratory Medicine in the Department of Laboratory Medicine and Pathology, as well as Medical Director of Clinical Pathology at University of Minnesota Medical Center, Fairview. In addition to his duties on the Residency Advisory Committee, Dr. Eckfeldt serves as the University of Minnesota Medical Center, Fairview, Site Director for the Residency Program and instructs residents during their chemistry rotation.

Educational Background

• University of Pennsylvania, Philadelphia, PA (1967), B.S. (Chemistry)
• Cornell University, Ithaca, NY (1969), M.S. (Physical Chemistry)
• University of Pennsylvania, Philadelphia, PA (1975), Ph.D. (Biophysics)
• University of Pennsylvania, Philadelphia, PA (1976), M.D.
• University of Minnesota, Minneapolis, MN (1978), Residency (Clinical and Chemical Pathology)

Board Certification

Clinical and Chemical Pathology, Clinical Chemistry

Professional Background

• Research Chemist, group leader in a surfactant application laboratory, Rohm and Haas Company, Spring House, PA, 1969 - 1971
• NSF Fellow and NIH Medical Scientist Training Program Fellow, University of Pennsylvania, Philadelphia, PA, M.D./Ph.D. training, 1971 - 1976
• Resident in clinical pathology, University of Minnesota, Minneapolis, MN, 1976 - 1978
• Assistant Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 1978 - 1985
• Chief of Clinical Chemistry and Toxicology, Veterans Affairs Medical Center, Minneapolis, MN, 1978 - 1985
• Associate Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 1985 - 1992
• Director of Clinical Chemistry, University of Minnesota Medical Center, Fairview, Minneapolis, MN, 1985 - 1992
• Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 1992 – 2005
• Ellis S. Benson endowed Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 2005 - present  
• Director, Clinical Chemistry, University of Minnesota Medical Center, Fairview, Minneapolis, MN, 1992 - 1996
• Director, Clinical Laboratories, University of Minnesota Medical Center, Fairview, Minneapolis, MN, 1996 - 1997
• Medical Director, Clinical Pathology, University of Medical Center, Fairview, Minneapolis, MN, 1996 - present
• Chief of Staff, University of Minnesota Medical Center, Fairview, Minneapolis, MN , 2003 - 2004
• Vice Chair for Clinical Affairs, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis MN, 2002 - present

Professional Memberships

• American Association for Clinical Chemistry, 1978 - present
• Academy of Clinical Laboratory Physicians and Scientists, 1979 - present
• Minnesota Society of Pathologists, 1979 - present
• Minnesota Department of Health Ad Hoc Technical Advisory Committee on Newborn Screening, Chair 1993 - 1996 and member 2004 - present
• Sigma Xi, 1980 - present
• College of American Pathologists, 1981 - present
• American Medical Association, 1985 - present
• Minnesota Medical Association, 1985 - present
• Hennepin County Medical Association, 1985 - present
• American Society for Human Genetics, 1995 - present

Research Activities

Dr. Eckfeldt is an active participant in numerous NIH-sponsored research studies.

Publications

Dr. Eckfeldt has published extensively on topics including lipids, lipoprotein, and genetic markers as risk factors for cardiovascular disease, hypertension, and iron overload disorders.  

• Bennett ST, Eckfeldt JH, Belcher J, Connelly D. Certification of Cholesterol Measurements by the National Reference Method Laboratory Network with Routine Clinical Specimens: Effects of Network Laboratory Bias and Imprecision. Clin Chem 1992;38:651-657.
• Eckfeldt JH, Copeland KC. Accuracy Verification and Identification of Matrix Effects: The CAP Protocol. Arch Pathol Lab Med 1993;117:381-386.
• Ross J, Meyers G, Gilmore B, Cooper GR, Naito HK, Eckfeldt JH. Matrix effects and Accuracy of Cholesterol Analysis in North American Hospitals and Independent Laboratories. Arch Pathol Lab Med 1993;117:393-400.
• Tsai MY, Suess P, Schwichtenberg K, Eckfeldt JH, Yuan J, Tuchman M, Hunninghake D. Determination of Apolipoprotein E Genotypes by Single-strand Conformational Polymorphism. Clin Chem 1993;39:121-124.
• Eckfeldt JH, Shen Y-L, Chambless LE. Short-term, Within-person Variability in Clinical Chemistry Test Results. Arch Pathol Lab Med 1994;48:496-500.
• Folsom AR, Eckfeldt JH, Weitzman S, Ma J, Chambless LE, Barnes RW, Cram KB, Hutchinson RG. Relation of Carotid Artery Wall Thickness to Diabetes Mellitus, Fasting Glucose and Insulin, Body Size, and Physical Activity. Stroke 1994;25:66-73.
• Lofgren RP, Wilt TJ, Nichol KL, Crespin L, Pluhar R, Eckfeldt J. The Effect of Fish Oil Supplements on Blood Pressure. Am J Public Health 1993;83:267-9.
• Larosa JC, Applegate W, Crouse JR, Hunninghake DB, Knopp R, Eckfeldt JH, Davis CE, Gordon DJ. Cholesterol Lowering in the Elderly; Results of the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study. Arch Intern Med 1994;154:529-39.
• Folsom AF, Ma J, Eckfeldt JH, Shahar E, Wu KK. Plasma Phospholipid Fatty Acid Composition and Factor VII Coagulant Activity. Arteriosclerosis 1994;111:199-207.
• Kritchevsky SB, Shimakawa T, Tell GS, Dennis B, Carpenter M, Eckfeldt JH, Peacher-Ryan H, Heiss G. Dietary Antioxidants and Carotid Artery Wall Thickness: The ARIC Study. Circulation 1995;92:2142-50.
• Beheshti I, Wessels LM, Eckfeldt JH. EDTA-Plasma vs Serum Differences in Cholesterol, High-Density-Lipoprotein Cholesterol, and Triglycerides as Measured by Several Methods. Clin Chem 1995;40:2099-2092.
• Folsom AR, Ma J, McGovern PG, Eckfeldt JH. Relationship between Plasma Phospholipids Saturated Fatty Acids and Hyperinsulinemia. Metabolism 1996;45:223-8.
• Eckfeldt JH. Direct LDL. A Cost-effective Replacement for the Friedewald Equation? Arch Pathol Lab Med 1996;120:15-7 Editorial.
• Doumas BT, Eckfeldt JH. Errors in Measurement of Total Bilirubin: A Perennial Problem. Clin Chem 1996;42:845-8 Editorial.
• Austin MA, Ordovas JM, Eckfeldt JH, Tracy R, Boerwinkle E, Lalouel J-M, Printz M. Guidelines for the National Heart, Lung and Blood Institute Working Group on Blood Drawing, Processing, and Storage for Genetic Studies. Am J Epidemiol 1996;144:437-41.
• Higgins M, Province M, Heiss G, Eckfeldt J, Ellison RC, Folsom AR, Rao DC, Sprafka JM, Williams R. NHLBI Family Heart Study: Objectives and design. Am J Epidemiol 1996;143:12-19-28.
• Jacques PF. Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rosen R. Relations between folate status, a common mutation in methlyenetrtrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7-9.
• Ma J, Folsom AR, Lewis L, Eckfeldt JH. Relation of plasma phospholipid and cholesterol ester fatty acid composition to carotid artery intima-media thickness: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr 1997;65:551-559.
• Pankow JS, Folsom AR, Province MA, Rao DC, Eckfeldt J, Heiss G, Shahar E, Wu KK. Family History of Coronary Heart Disease and Hemostatic Variables in Middle-aged Adults. Thromb Haemost 1997;77:87-93.
• Garg UC, Zheng ZJ, Folsom AR, Moyer YS, Tsai MY, McGovern P, Eckfeldt JH. Short-Term and Long-term Variability of Plasma Homocysteine Measurement. Clin Chem 1997;43:141-5.
• Folsom AR, Liao F, Szklo M, Smith R, Stevens J, Eckfeldt JH. A Prospective Study of Coronary Heart Disease in Relation to Fasting Insulin, Glucose, and Diabetes. Diabetes Care 1997;20:93542.
• Iribarren C, Folsom AR, Jacobs DR, Gross MD, Belcher JD, Eckfeldt JH. Association of Serum Vitamins Levels, LDL Susceptibility to Oxidation, and Autoantibodies against MDA-LDL with Carotid Atherosclerosis. Arterioscler Thromb Vasc Biol 1997;17:1171-7.
• Eckfeldt JH, Bruns D. Another Step toward Standardization of Methods for Measuring Hemoglobin A1c. Clin Chem 1997;43:1811-1813 Editorial.
• Iribarren C, Folsom AR, Jacobs DR Jr, Gross MD, Eckfeldt JH, Kritchevsky SB. Patterns of Covariation of Serum Beta-carotene and Alpha-tochoperol in Middle Aged Adults: The Athersclerosis Risk in Communities (ARIC) Study. Nutr Metab Cardiovasc Dis 1997;7:445-58.
• Zeng S-J, Folsom AR, Shahar E, McGovern PJ, Eckfeldt JH. Association of Plasma Ratty Acid Composition with Lower Extremity Arterial Disease: The Atherosclerosis Risk in Communities (ARIC) Study. Nutr Metab Cardiovasc Dis 1997;7:360-70.
• Folsom AR, Pankow JS, Williams RR, Evans GW, Province MA, Eckfeldt JH. Fibrinogen, Plasminogen Activator Inhibitor-1, and Carotid Intimal-medial Wall Thickness in the NHLBI Family Heart Study. Thromb Haemost 1998;79:400-4.
• Garg UC, Arnett DK, Evans G, Eckfeldt JH. No Association between Factor V Leiden Mutation and Coronary Heart Disease or Carotid Intima Medial Thickness: The NHLBI Family Heart Study. Thromb Research 1998;89:298-93.
• Folsom AR, Nieto J, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, Hess DKL, Davis CE. Prospective Study of Coronary Heart Disease Incidence in Relation to Fasting Total Homocysteine, Related Genetic Polymorphisms, and B Vitamins: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1998;98:204-210.
• Pankow JS, Folsom AR, Province MA, Rao DC, Williams RR, Eckfeldt J, Sellers TA, Segregation analysis of plasminogen activator inhibitor-1 and fibrinogen levels in the NHLBI family heart study. Arterioscler Thromb Vasc Biol 1998;18:1559-67.
• Hopkins PN, Hunt SC, Schreiner PJ, Eckfeldt JH, Borecki IB, Ellison CR, Williams RR, Siegmund KD. Lipoprotein (a) interactions with lipid and non-lipid risk factors in patients with early onset coronary artery disease: results from the NHLBI Family Heart Study. Atherosclerosis 1998;141:333-45.
• Iribarren C, Sempos CT, Eckfeldt JH, Folsom AR, Lack of association between ferritin level and measures of LDL oxidation: the ARIC study. Atherosclerosis Risk in Communities. Atherosclerosis 1998;139:189-95.
• Ellison RC, Zhang Y, Myers RH, Swanson JL, Higgins M, Eckfeldt J. Lewis blood group phenotype as an independent risk factor for coronary heart disease (the NHLBI Family Heart Study). Am J Cardiol 1999;83:345-8.
• Peacock JM, Folsom AR, Arnett DK, Eckfeldt JH, Szklo M. Relationship of Serum and Dietary Magnesium to Incident Hypertension: The Atherosclerosis Risk in Communities (ARIC) Study. Ann Epidemiol 1999;9:159-165.
• Shahar E, Boland LL, Folsom AR, Tockman MS, McGovern PG, Eckfeldt JH. Docosahexaenoic Acid and Smoking-Related Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 1999;159:1780-1785.
• Zheng ZJ, Folsom AR, Ma J, Arnett DK, McGovern PG, Eckfeldt JH. Plasma Fatty Acid Composition and 6-year Incidence of Hypertension in Middle-aged Adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 1999;150:492-500.
• Coon H, Leppert MF, Kronenberg F, Province MA, Myers RH, Arnett DK, Eckfeldt JH, Heiss G, Williams RR, Hunt SC, Evidence for a major gene accounting for mild elevation in LDL cholesterol: the NHLBI Family Heart Study. Annals of Human Genetics. 1999;63:401-12.
• Nelson JJ, Liao D, Sharrett AR, Folsom AR, Chambless LE, Shahar E, Szklo M, Eckfeldt J, Heiss G. Serum Albumin Level as a Predictor of Incident Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 2000;151:468-477.
• Kronenberg F, Rich SS, Sholinsky P, Arnett DK, Province MA, Myers RH, Eckfeldt JH, Hunt SC, Williams RR. Insulin in Hypertension in the Family Heart Study. Am J Hypertension 2000;13:240-50.
• Salomma V, Pankow JS, Heiss G, Cakir, B, Eckfeldt JH, Ellison RC, Myers RH, Hiller KN, Brantley, KR, Weston BW. Genetic Background of Lewis Negative Blood Group Phenotype and its Association with Atherosclerotic Disease in the NHLBI Family Heart Study. J Intern Med 2000;247:689-98.
• Williams RR, Rao DC, Ellison RC, Arnett DK, Heiss G,. Oberman A, Eckfeldt JH, Leppert MF, Province MA, Mockrin SC,. Hunt SC. NHLBI Family Blood Pressure Program: Methodology and Recruitment in the HyperGEN network. Hypertension Genetic Epidemiology Network. Annals of Epidemiol. 2000;10:389-400.
• Hong Y, Leppert MF, Lin J, Hunt SC, Rich SS, Arnett DK, Myers RH, Eckfeldt JH, Williams RR, Province MA. No Linkage of VLDL Receptor Gene and Fasting Serum Insulin or HOMA Insulin Resistance Index. Metabolism 2000;49:293-7.
• Wilk JB, Djousse L, Borecki , Atwood LD, Hunt SC, Rich SS, Eckfeldt JH, Arnett DK, Rao DC, Myers RH, Segregation Analysis of Serum Uric Acid in the NHLBI Family Heart Study. Human Genetics 2000;106:355-9.
• Williams RR, Rao DC, Ellison RC, Arnett DK, Heiss G, Oberman A, Eckfeldt JH, Leppert MF, Province MA, Mockrin SC, Hunt SC. NHLBI family blood pressure program: methodology and recruitment in the HyperGEN network. Hypertension genetic epidemiology network. Annals Epidemiol 2000;10:389-400.
• Muntner P, Coresh J, Smith JC, Eckfeldt J, Klag MJ. Plasma Llipids and Risk of Developing Renal Dysfunction: the Atherosclerosis Risk in Communities Study. Kidney Internat 2000;58:293-301.
• Kronenberg F, Rich SS, Sholinsky P, Arnett DK, Province ME, Myers RH, Eckfeldt JH, Williams RR, Hunt SC. Insulin and hypertension in the NHLBI Family Heart Study: a Sibpair Approach to a Controversial Issue. Am J Hyperten 2000;13:240-50, 2000.
• Tsai MY, Arnett DK, Eckfeldt JH, Williams RR, Ellison C. Plasma Homocysteine and its Association with Carotid Intimal-medial Wall Thickness and Prevalent Coronary Heart Disease: NHLBI Family Heart Study. Atherosclerosis. 2000;151:163-168.
• Pankow JS, Arnett DK, Borecki IB, Hunt SC, Eckfeldt JH, Folsom AR, Djousse L. No Association Between the Angiotensin Converting Enzyme Insertion/Deletion Polymorphism and Plasminogen. Blood, Coag, Fibrinolysis 2000;11:551-8.
• Province MA. Arnett DK. Hunt SC. Leiendecker-Foster C. Eckfeldt JH. Oberman A. Ellison RC. Heiss G. Mockrin SC. Williams RR. Association between the alpha-adducin gene and hypertension in the HyperGEN Study. American Journal of Hypertension. 2000;13(6 Pt 1):710-8.
• Hunt SC, Kronenberg F, Eckfeldt JH, Hopkins PN, Myers RH, Heiss G. Association of Plasma Bilirubin with Coronary Heart Disease and Segregation of Bilirubin as a Major Gene. Atherosclerosis 2001;154:747-54.
• DeWan AT, Arnett DK, Atwood LD, Province MA, Lewis CE, Hunt SC, Eckfeldt J. A Genome Scan for Renal Function among Hypertensives: the HyperGEN Study. Am J Hum Genet 2001;68:136-44.
• Pankow JS, Folsom AR, Cushman M, Borecki IB, Hopkins PN, Eckfeldt JH, Tracy RP. Familial and Genetic Determinants of Systemic Markers of Inflammation: the NHLBI Family Heart Study. Atherosclerosis 2001;154: 681-689.
• Grimm RH, Margolis KL, Papadermetriou V, Cushman WC, Ford CE, Bettercourt J, Alderman MH, Basile JN, Black HR, De Quattro V, Eckfeldt J, Hawkins M, Perry HM, Proschan M for the ALLHAT Collaborative Research Group. Baseline Characteristics of Participants in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Hypertension 2001;37:19-27.
• Rasmussen ML, Folsom AR, Catellier DJ, Tsai MY, Garg U, Eckfeldt JH. A Prospective Study of Coronary Heart Disease and the Hemochromatosis Gene (HFE) C282Y Mutation: the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis 2001;154:739-46.
• Folsom AR. Pankow JS. Tracy RP. Arnett DK. Peacock JM. Hong Y. Djousse L. Eckfeldt JH. The Investigators of the NHBLI Family Heart Study. Association of C-reactive protein with markers of prevalent atherosclerotic disease. Am J Cardiol 2001;88:112-7.
• Weisberg IS. Jacques PF. Selhub J. Bostom AG. Chen Z. Curtis Ellison R. Eckfeldt JH. Rozen R. The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 2001;156:409-15.
• Coon H, Leppert MF, Eckfeldt JH. Oberman A, Myers RH, Peacock JM, Province MA aAtherosclerosis, Hopkins PN, Heiss G. Genome-wide linkage analysis of lipids in the Hypertension Genetic Epidemiology Network (HyperGEN) Blood Pressure Study. Arterioscler Thromb Vasc Biol 2001;21:1969-76.
• Djousse L, Pankow JS, Eckfeldt JH, Folsom AR, Hopkins PN, Province MA, Hong Y, Ellison RC. Relation between Dietary Linolenic Acid and Coronary Artery Disease in the National Heart, Lung, and Blood Institute Family Heart Study. Am J of Clin Nutrit 2001;74:612-9.
• Djousse L, Myers RH, Province MA, Hunt SC, Eckfeldt JH, Evans G, Peacock JM, Ellison RC. Influence of Apolipoprotein E, Smoking and Alcohol Intake on Carotid Atherosclerosis: National Heart, Lung, and Blood Institute Family Heart Study. Stroke 2002;33:1357-61.
• Kronenberg F, Coon H, Ellison RC, Borecki I, Arnett DK, Province MA, Eckfeldt JH, Hopkins PN, Hunt SC. Segregation analysis of HDL cholesterol in the NHLBI Family Heart Study and in Utah pedigrees. Eur J Hum Gen 2002;10:367-74.
• Coon H, Eckfeldt JH, Leppert MF, Myers RH, Arnett DK, Heiss G, Province MA, Hunt SC. A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study. Human Genetics 2002;111:263-9.
• Hanson NQ, Eckfeldt JH, Schwichtenberg K, Aras O, Tsai MY. Interlaboratory variation of plasma total homocysteine measurements: results of three successive homocysteine proficiency testing surveys. Clin Chem 2002;48:1539-45.
• McLaren CE, Barton JC, Adams PC, Harris EL, Acton RT, Press N, Reboussin DM, McLaren GD, Sholinsky P, Walker AP, Gordeuk VR, Leiendecker-Foster C, Dawkins FW, Eckfeldt JH, Mellen BG, Speechley M, Thomson E. Hemochromatosis and Iron Overload Study Research Investigators, Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adults. Am J Med Sciences 2003;325:53-62.
• Wang L, Folsom AR, Zheng Z-J, Pankow JS, Eckfeldt JH. Plasma fatty acid composition and incidence of diabetes in middle-aged adults: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr 2003;78:91-8.
• Wang L, Folsom AR, Eckfeldt JH. Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Nut Met Cardiovascular Dis 2003;13:256-66.
• Djousse L, Hunt SC, Arnett DK, Province MA, Eckfeldt JH, Ellison RC. Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutrit 2003;78:1098-102.
• Hopkins PN, Heiss G, Ellison RC, Province MA, Pankow JS, Eckfeldt JH, Hunt SC. Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study. Circulation 2003;108:519-23.
• Rao DC, Province MA, Leppert MF, Oberman A, Heiss G, Ellison RC, Arnett DK, Eckfeldt JH, Schwander K, Mockrin SC, Hunt SC. HyperGEN Network. A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network. Am J Hyperten. 2003;16:148-50.
• Jacques PF, Bostom AG, Selhub J, Rich S, Ellison RC, Eckfeldt JH, Gravel RA, Rozen R, National Heart, Lung and Blood Institute, National Institutes of Health. Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis 2003;166:49-55.
• Rahman M, Brown CD, Coresh J, Davis BR, Eckfeldt JH, Kopyt N, Levey AS, Nwachucku C, Pressel S, Reisin E, Walworth MD for the ALLHAT Collaborative Research Group. The Prevalence of Reduced Glomerular Filtration Rate in Older Hypertensive Patients and Its Association With Cardiovascular Disease: A Report From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Arch Intern Med 2004;164:969-976.
• Davis BR, Ford CE, Boerwinkle E, Arnett D, Eckfeldt J, Black H. Imputing gene-treatment interactions when the genotype distribution is unknown using case-only and putative placebo analyses--a new method for the Genetics of Hypertension Associated Treatment (GenHAT) study. Statistics Med 2004;23:2413-27.
• Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA. Hopkins PN. Weiss R. Hunt SC. Leppert MF. NHLBI Family Heart Study. TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study. Atherosclerosis 2004;174:357-62.
• Djousse L, Arnett DK, Eckfeldt JH, Province MA, Singer MR, Ellison RC. Alcohol consumption and metabolic syndrome: does the type of beverage matter? Obesity Res 2004;12:1375-85.
• Arnett DK, Miller MB, Coon H, Ellison RC, North KE, Province M, Leppert M, Eckfeldt JH. Genome-wide linkage analysis replicates susceptibility locus for fasting plasma triglycerides: NHLBI Family Heart Study. Human Genetics 2004;115:468-74.
• Djousse L, Pankow JS, Arnett DK, Eckfeldt JH, Myers RH, Ellison RC. Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutrit 2004;80:1639-44.
• Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA. Hopkins PN. Weiss R. Hunt SC. Leppert MF. NHLBI Family Heart Study. TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study. Atherosclerosis 2004;174:357-62.
• Djousse L, Arnett DK, Eckfeldt JH, Province MA, Singer MR, Ellison RC. Alcohol consumption and metabolic syndrome: does the type of beverage matter? Obesity Res 2004;12:1375-85.
• Arnett DK, Miller MB, Coon H, Ellison RC, North KE, Province M, Leppert M, Eckfeldt JH. Genome-wide linkage analysis replicates susceptibility locus for fasting plasma triglycerides: NHLBI Family Heart Study. Human Genetics 2004;115:468-74.
• Rahman M, Pressel S, Davis BR, Nwachuku C, Jackson T. Wright JT, Whelton PK, Barzilay J, Batuman V, Eckfeldt JH, Farber M, Henriquez M, Kopyt N, Louis GT, Saklayen M, Stanford C, Walworth C, Ward H, Wiegmann T for the ALLHAT Collaborative Research Group. Renal Outcomes in High-Risk Hypertensive Patients Treated With an Angiotensin-Converting Enzyme Inhibitor or a Calcium Channel Blocker vs a Diuretic: A Report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med 2005;165:936-46.
• Djousse L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA, Ellison RC. Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: The NHLBI Family Heart Study. Circulation 2005;in press.
• Adams PC, Reboussin DR, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P for the Hemochromatosis and Iron Overload Screening Study Research Investigators. Hemochromatosis and Iron Overload Screening (HEIRS) Study: Screening of a primary care population of 101,168 persons of diverse ethnic background. N Engl J Med 2005;352:1769-78.
• Djousse L, Rautaharju PM, Hopkins PN, Whitsel EA, Arnett DK, Eckfeldt JH, Province MA, Ellison C. Dietary linolenic acid and adjusted QT and JT intervals in the NHLBI Family Heart Study. J Am College Cardiol 2005;in press.
• Arnett DK, Davis BR, Ford CE, Boerwinkle E, Leiendecker-Foster C, Miller MB, Black H, Eckfeldt JH. Pharmacogenetic association of the angiotensin converting enzyme insertion-deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: The GenHAT Study. Circulation 2005;in press.