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  Home > About Lab Medicine and Pathology > Faculty and Staff > Myron Gross, Ph.D.
 

Myron Gross, Ph.D.


MEDPATHOLOGY Myron Gross - Portrait
Contact Information

Phone: 612-624-5417
Fax: 612-625-8950

Email:

gross001@umn.edu

Address:

MMC 609 Mayo
8609
420 Delaware
Minneapolis, MN 55455




Associate Professor

Research Interests

  • Biomarker development/translational research
  • Molecular/biochemical epidemiology
  • Antioxidants, oxidative damage and risk of cardiovascular disease
  • DNA repair and genetic susceptibility in the risk of breast cancer
  • Early detection of pancreatic prostate cancer
  • Dietary and genetic factors in Alzheimer’s and successful aging

 

Educational Background

  • North Dakota State University (1974), B.S. (Animal Science)
  • North Dakota State University (1977), M.S. (Animal Science)
  • University of Minnesota (1985), Ph.D. (Human Nutrition/Biochemistry)

Professional Background

  • Research Fellowship, National Research Service Award , Endocrine Research Unit, Mayo Clinic, Rochester, MN, 1984 - 1987
  • Research Associate, University of Minnesota, Division of Epidemiology, 1987 – 1990
  • Assistant Professor, University of Minnesota, Division of Epidemiology, 1990 - 1998
  • Director of Molecular Epidemiology and Biomarker Research Laboratory, University of Minnesota, 1991-present
  • Faculty Member, Nutrition, University of Minnesota School of Public Health, Minneapolis, MN, 1996-present
  • President of the Plant Phenolics and Health Research Interest Group, 1998-Present
  • Associate Professor, University of Minnesota, Division of Epidemiology, 1998 - 1999
  • Adjunct Associate Professor, Division of Epidemiology, University of Minnesota, 1998 - present
  • Associate Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 1999-2006
  • Professor, University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 2007-present

Publications

  • Clevidence BA, Khachik F, Brown ED, Nair PP, Wiley ER, Prior RL, Cao G, More DW, Stone W, Gross M, Kramer TR. Consumption of Carotenoid-rich vegetables: Oxidation, immune response and bioavailability in humans. Chapter in Antioxidant Methodology (eds, Aruoma & Halliwell) Am Oil Chem Soc Press, 1996.
  • Iribarren C, Belcher JD, Jacobs DR, Gross M, Schreiner P, Sidney S. Pelationship of lipoprotein, apolipoproteins, triglycerides and lipid ratios to low plasma total cholesterol: The CARDIA Study. Journal of Cardiovascular Risk 3:391-396, 1996.
  • Comstock GW, Alberg AJ, Huang HY, Wu K, Burke AE, Hoffman SC, Noprkus EP, Gross M, Culter RG, Morris JS, Spate VL, Helzlsouer KJ. The Risk of Developing Lung Cancer Associated with Antioxidants in the Blood: Ascobic Acid, Carotenoids, Alpha-Tocopherol, Selenium, and Total Peroxyl Radical Absorbing Capacity. Cancer Epidemiology, Biomarkers, and Prevention, 6(11):907-16, 1997.
  • Iribarren C, Jacobs DR, Jr, Sidney S, Claxton AJ, Gross MD, Blackburn H. Serum total cholesterol and risk of respiratory disease in a large cohort. International Journal of Epidemiology, 26:1191-1202, 1997.
  • Brown JE, Jacobs DR, Hartman RJ, Barosso GM, Stang JS, Gross MD, Zeuske MA. Predictors of Red Cell Folate Levels in Women Attempting Pregnancy: Results from the DIANNA Project. JAMA 277:548-552, 1997.
  • Gross MD, Snowdon DA. Plasma Antioxidant Concentrations in a population of Elderly Women: Findings from the Nun Study. Nutrition Research 16(11-12):1881-1890, 1996.
  • Gross MD, Bishop TD, Belcher JD, Jacobs DR, Jr. The Solubilization of Beta Carotene in Culture Media. Nutrition and Cancer 27(2):174-176, 1997.
  • Gross MD, Bishop TD, Belcher JD, Jacobs DR, Jr. The Induction of HL-60 Cell Differentiation by Carotenoids. Nutrition and Cancer 27(2):169-173, 1997.
  • Gross MD, Pfiffer M, Martini M, Campbell D, Slavin J, Potter J. Quantition of Quercetin Metabolites in Human Urine. Cancer Epidemiology, Biomarkers, and Prevention 5(9):711-720, 1996.
  • Jyonouchi H, Sun S, Gross MD. Effects of Various Carotenoids on Cloned, Effector-stage T-helper Cell Activity. Nutrition and Cancer 26(3):313-324, 1996.
  • Veenstra TD, Gross MD, Hunziker W, Kumar R. Identification of Metal Binding Sites in Rat Brain Calcium-Binding Protein. Journal of Biological Chemistry, 207(51):30353-30358, 1996.
  • Boosalis MG, Snowdon DA, Tully CL, Gross MD. The Acute Phase of Response and Plasma Antioxidant Concentrations in Older Women: Finding from the Nun Study. Nutrition 12:475-478, 1996.
  • Snowdon DA, Gross MD, Butler SM. Antioxidants and Reduced Functional Capacity in the Elderly: Findings from the Nun Study. Journal of Gerontology: Medical Sciences, 51:M10-M16, 1996.
  • Martini MC, Campbell DR, Gross MD, Grandits GA, Potter JD, Slavin JL. Plasma Carotenoids as Biomarkers of Vegetable Intake: The University of Minnesota Cancer Prevention Research Unit Feeding Studies. Cancer Epidemiology, Biomarkers, and Prevention, 4:491-496, 1995.
  • Jyonouchi H, Sun S, Tomita Y, Gross MD. Astaxanthin, a Carotenoid without Vitamin A Activity, Augments Antibody Responses with Murine T-Helper Clones and Suboptimal Doses of Antigen. Journal of Nutrition, 125:2483-2492, 1995
  • Jyonouchi H, Sun S, Tonita Y, Gross MD. Effect of Carotenoids on in vitro Immunoglobulin Production by Human Peripheral Blood Mononuclear Cells: Astacanthin, a Carotenoid without Vitamin A Activity, Enhances In Vitro Immunoglobulin Production in Response to a T-Dependent Stimulant and Anitgen. Nutr Cancer, 23:171-183, 1995.
  • Gross MD, Prouty CB, Jacobs DR, Jr. Stability of Carotenoids and Tocopherol During Blood Collection and Processing Procedures. Clincal Chem, 41:943-944, 1995.
  • Campbell D, Gross MD, Martini M, Gradits G, Slavin J, Potter J. Plasma Cartenoids as Biomarkers of Vegetable and Fruit Intake. Cancer Epidemiology, Biomarkers, and Prevention, 4:491-496, 1995.
  • Iribarren C, Folsom AR, Jacobs DR, Jr, Gross MD, Belcher JD, Eckfeldt JH. Association of Serum Vitamin Levels, LDL Susceptibility to Oxidation and Autoantibodies against Oxidized MDA-LDL with Carotid Atherosclerosis - A Case Control Study. Artioscler Thromb Vasc Biol 17:1171-1177, 1997.
  • Kumar R, Hunziker W, Gross MD, Naylor S, Londowski J, Schaefer J. The Highly Efficient production of full-length and mutant rat brain calcium-binding proteins in a bacterial expression system. Arch Biochem Biophys 308:311-317, 1994.
  • Jyonouchi H, Zhang L, Gross MD, Tomita Y. Immunomodulating actions of carotenoids: enhancement of in vivo and in vitro antibody production to T-dependent antigens. Nutr Cancer 21:47-58, 1994.
  • Gross MD, Gapstur SM, Chaussee M, Potter JD. Evidence for the formation of muliplt types of acetaldehyde-haemoglobin adducts. Alcohol 29:31-41, 1994.
  • Belcher JD, Balla J, Balla G, Jacobs DR, Jr., Gross MD, Vercellotti GM. Vitamin E, LDL and Endothelium: Brief Oral Vitamin Supplementation Prevents Oxidized LDL-mediated Vascular Injury in vitro. Arteriosclerosis and Thrombosis 13(120:1779-1789, 1993.
  • Nieto J, Iribarren C, Gross MD, Comstock G, Cutler R. Uric Acid and Serum Antioxidant Capacity: A Reaction to Atherosclerosis? Atherosclerosis, 148(1):131-9, 2000.
  • Gross M, Kruisselbrink T, Anderson K, Lang N, McGovern P, Kadlubar F. The Distribution and Concordance of N-Acetyltransferase Genotype and Phenotype in an American Population. CEBP 1999;8(8):683-92.
  • Iribarren C, Jacobs D, Sidney S, Gross MD, Eisner MD. Cigarette Smoking, Alcohol Consumption, and Risk of ARDS: a 15-year Cohort Study in a Managed Care Setting. CHEST 117(1):163-168, 2000.
  • Jyonouchi H, Sun S, Iijima K, Gross MD. Antitumor Activity of Astaxanthin and its Mode of Action. Nutrition and Cancer: An International Journal, 36(1):59-65, 2000.
  • Klaus W, Grzesiek ST, Labhardt AM, Buchwald P, Hunziker W, Gross MD, Kallick D. NMR Investigation and Secondary Structure of Domains I and II of Rat Brain Calbindin D28k(1-93). Eur. J. Biochem, 262(3): 933-938, 1999.
  • Smith-Warner S, Elmer P, Tharp T, Fosdick L, Randall B, Gross M, Wood J, Potter J. Increasing Vegetable and Fruit Intake - Randomized Intervention and Monitoring in an At-Risk Population. CEBP 9:307-317, 2000.
  • Forman MR, Zhang J, Gunter E, Yao SX, Gross M, Qiao YL, Graubard BI, Taylor PR, Keith S, Maher M. Season-Specific Correlation Between Dietary Intake of Fruits and Vegetables and Levels of Serum Biomarkers Among Chinese Tin Miners at High Risk of Lung Cancer. Annals of NY Academy of Sciences, 889:230-239; 2000.
  • Bostick RM, Fosdick L, Grandits GA, Grambsch P, Gross MD, Louis TA. Effect of Calcium Supplementation on Serum Cholesterol and Blood Pressure. A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial. Arch Fam Med 9:31-38; 2000.
  • Zheng W, Xie D, Heimel A, Wen W, Cerhan J, Gross M, Campbell D, Folsom A. Genetic Polymorphisms of Glutathione S-transferase M1 and T1, Well done Meat Intake, and Cigarette Smoking in Relation to Risk of Breast Cancer among Post-Menopausal Women. Breast Cancer Research and Treatment 2002, In Press.
  • Kritchevsky SB, Bush AJ, Pahor M, Gross MD. Carotenoid and Lipids/Lipoprotein Correlates of the Susceptibility of Low-density Lipoprotein to Oxidation in Humans, in: Basu TK, Temple NJ, Garg ML, eds. Antioxidants in Human Health and Disease. CAB International. 1999:71-83.
  • Kroenke CH, Pereira MA, Slattery ML, Van Horn L, Gross MD, Jacobs Jr DR. Consumption of Minimally Processed Plant Food is Associated with Reduced Ten-Year Incidence of Elevated Blood Pressure in Young Black and White Adults: The CARDIA Study.
  • Comstock, George W., Burke A, Hoffman S, Norkus E, Gross M, Helzlsouer. The Repeatability of Serum Carotenoid, Retinoid, and Tocopherol Concentrations in Specimens of Bloods Collected 15 years Apart. CEBP, 10:65-68; 2001.
  • Snowdon DA, Gross MD. Plasma Lycopene and Longevity: Findings from the Nun Study.
  • Reich EE, Montine KS, Gross MD, Roberts LJ 2nd, Swift LL, Morrow JD, Montin TJ. Interactions between appolipoprotein E gene and dietary alpha-tocopherol influence cerebral oxidative damage in aged mice. J Neurosci 2001;21(16):5993-9.
  • Gross MD, Martini MC, Campbell Dr, Grandits GA, Potter JD, Slavin JL. A Cross-Sectional Study of Fruit and Vegetable Intake and Urinary Excretion of Specific Phenolic Compounds.
  • Martini MC, Gross MD, Campbell Dr, Grandits GA, Potter JD, Slavin JL. A Feeding Study of Fruit and Vegetable Intake and Urinary Excretion of Specific Phenolic Compounds.
  • Deitz A, Zheng W, Leff MA, Gross M, Xiao G, Doll M, Wen W, Folsom A, and Hein D. N-Acetyltransferase-2 (NAT2) Genetic Polymorphism, Well-Done Meat Intake, and Breast Cancer Risk Among Post-Menopausal Women. CEBP 2000;9:905-910.
  • Kritchevsky S, Bush A, Pahor M, Gross M. Serum Carotenoids and Markers of Inflammation in Non-Smokers. Am J Epi 2000;152(11):1065-71.
  • Periera AM, Jacobs Jr DJ, Pins JJ, Raatz SK, Gross MD, Slavin JL, Seaquist ER. The Effect of Whole Grains on Insulin Sensitivity in Overweight Hyperinsulinemic Adults. Am J Clin Nutr, 75(5):848-855, 2002.
  • Arts ICW, Jacobs Jr. DR, Harnack LJ, Gross MD, Folson AR. Dietary Catechins: Intake and Relation to Coronary Heart Disease Death Among Postmenopausal Women. Epidemiology, 12(6):668-675, 2001.
  • Gross MD, Yu X, Hannan P, Prouty C, Jacobs DR. Lipid standardization of serum fat-soluble antioxidant concentrations: the YALTA study. Am J Clin Nutr 77:458-66, 2003.
  • Anderson KE, Sinha R, Kulldorff M, Gross MD, Lang NP, Barber c, Harnack L, DiMagno E, Bliss R, Kadlubar FF. Meat Intake and Cooking Techniques: Associations with Pancreatic Cancer. Mutation Research 506-507:225-31, 2002.
  • Lee DH, Ha MH, Kim JR, Gross MD, Jacobs DR. Gamma-glutamyltransferase, alcohol, and blood pressure: A four year follow-up study. Ann Epidemiol 12:90-6, 2002.
  • Lee D-H, Ha M-H, Kim J-H, Christiani DC, Gross MD, Steffes M, Blomhoff R, Jacobs DR. Gamma-glutamyltransferase and type 2 diabetes-A 4 year follow up study. Diabetologia, In press, 2003.
  • Iribarren C, Lowry PW, Gross MD, Ludwig TS, Jacobs D. Influence of Total Serum Cholesterol and Lipid-Soluble Vitamins in Cell Mediated Immune Responses among Healthy Young Adults. Journal of Environmental and Nutrition Interactions 2:127-138, 1998.
  • Iribarren C, Folsom AR, Jacobs DR, Jr., Gross MD, Eckfeldt JH, Kritchevsky SB. Patterns of covariation of serum ß-carotene and a-tocopherol in middle-aged adults: The Atherosclerosis Risk in Communities (ARIC) Study. Nutr Metab Cardiovascular Dis 7:445-458, 1997.
  • Murtaugh MA, Jacobs DR, Yu X, Gross MD, Steffes M. Correlates of urinary albumin excretion in black and white young adults: the CARDIA Study. American Journal of Epidemiology, In Press, 2003.
  • Gross MD. Flavonoids and Cardiovascular Disease. Pharmaceutical Biology. 2004; Vol 42. Supplement pp 21-35.
  • Guettier JM, Georgopoulos A, Tsai MY, Radha V, Shanthirani S, Deepa R, Gross M, Rao G,.Mohan V. Polymorphisms in the Fatty Acid-Binding Protein 2 and Apolipoprotein C-III Genes Are Associated with the Metabolic Syndrome and Dyslipidemia in a South Indian Population. J Clin Endocrinol Metab 2005;90:1705-11.
  • Gross M, Steffes M, Jacobs DR, Jr., Yu X, Lewis L, Lewis CE, Loria CM. Plasma F2-isoprostanes and coronary artery calcification: the CARDIA Study. Clin Chem 2005;51:125-31.
  • Iribarren C, Gross MD, Darbinian JA, Jacobs DR, Jr., Sidney S, Loria CM. Association of lipoprotein-associated phospholipase A2 mass and activity with calcified coronary plaque in young adults: the CARDIA study. Arterioscler Thromb Vasc Biol 2005;25:216-21.
  • Gross M. Vitamin D and Calcium in the Prevention of Prostate and Colon Cancer: New Approaches for the Identification of Needs. Journal of Nutrition 2005; 135(2): 326-31
  • Wilson D. M., Wang Y, Cullen K, Baranowski T, Himes JH, Gross M, McClanahan B, Robinson T. (2004). "Assessing weight-related biochemical cardiovascular risk factors in African-American girls." Obesity Res 12 Suppl: 73S-83S.
  • Kris-Etherton PM, Lefevre M, Beecher GR, Gross MD, Keen CL, Etherton TD. Bioactive Compounds in Nutrition and Health-Research Methodologies for Establishing Biological Function: The Antioxidant and Anti-Inflammatory Effects of Flavonoids on Atherosclerosis. Annu Rev Nutr 2004; 24: 511-538.
  • Steffes MW, Gross MD, Schreiner PJ, Yu X, Hilner JE, Gingerich R, Jacobs DR, Jr. Serum adiponectin in young adults--interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA study. Ann Epidemiol 2004;14:492-8.
  • Thyagarajan B, Brott M, Mink P, Folsom AR, Anderson KE, Oetting WS, Gross MD. CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study. Cancer Letters 2004; 207:183-189.
  • Simon JA, Murtaugh MA, Gross MD, Loria CM, Hilner JE, Jacobs DR. Relation of ascorbic acid to coronary artery calcification: the Coronary Artery Disease in young Adults (CARDIA) Study. Am J Epidemiol 2004;159:581-8.
    Lee D-H, Gross MD, Jacobs DR. The association of serum carotenoids and tocopherols with g-glutamyltransferase; The CARDIA Study. Clin Chem 2004;50:582-88
  • Kris-Etherton PM, Lefevre M, Beecher GR, Gross MD, Keen CL, Etherton TD. Bioactive Compounds in Nutrition and Health-Research Methodologies for Establishing Biological Function: The Antioxidant and Anti-Inflammatory Effects of Flavonoids on Atherosclerosis. Annu Rev Nutr 2004; 24: 511-538.
  • Gross MD. Flavonoids and Cardiovascular Disease. Pharmaceutical Biology. 2004; Vol 42. Supplement pp 21-35.
  • Steffes MW, Gross MD, Schreiner PJ, Yu X, Hilner JE, Gingerich R, Jacobs DR, Jr. Serum adiponectin in young adults--interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA study. Ann Epidemiol 2004;14:492-8.
  • Thyagarajan B, Brott M, Mink P, Folsom AR, Anderson KE, Oetting WS, Gross M. CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study. Cancer Lett2004;207:183-9.
  • Simon JA, Murtaugh MA, Gross MD, Loria CM, Hulley SB, Jacobs DR, Jr. Relation of ascorbic acid to coronary artery calcium: the Coronary Artery Risk Development in Young Adults Study. Am J Epidemiol 2004;159:581-8.
  • Lee DH, Gross MD, Jacobs DR, Jr. Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study. Clin Chem 2004;50:582-8.
  • Wilson DM, Wang Y, Cullen K, Baranowski T, Himes JH, Gross M, McClanahan B, Robinson T. Assessing Weight-related Biochemical Cardiovascular Risk Factors in African American Girls. Obesity Research
  • Guettier JM, Georgopoulos A, Tsai MY, Radha V, Shanthirani S, Deepa R, et al. Polymorphisms in the Fatty Acid-Binding Protein 2 and Apolipoprotein C-III Genes Are Associated with the Metabolic Syndrome and Dyslipidemia in a South Indian Population. J Clin Endocrinol Metab 2005;90:1705-11.
  • Gross M, Steffes M, Jacobs DR, Jr., Yu X, Lewis L, Lewis CE, Loria CM. Plasma F2-isoprostanes and coronary artery calcification: the CARDIA Study. Clin Chem 2005;51:125-31.
  • Iribarren C, Gross MD, Darbinian JA, Jacobs DR, Jr., Sidney S, Loria CM. Association of lipoprotein-associated phospholipase A2 mass and activity with calcified coronary plaque in young adults: the CARDIA study. Arterioscler Thromb Vasc Biol 2005;25:216-21.

 


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